2024
DOI: 10.1186/s13148-024-01701-2
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Epigenetic scores derived in saliva are associated with gestational age at birth

Katie Mckinnon,
Eleanor L. S. Conole,
Kadi Vaher
et al.

Abstract: Background Epigenetic scores (EpiScores), reflecting DNA methylation (DNAm)-based surrogates for complex traits, have been developed for multiple circulating proteins. EpiScores for pro-inflammatory proteins, such as C-reactive protein (DNAm CRP), are associated with brain health and cognition in adults and with inflammatory comorbidities of preterm birth in neonates. Social disadvantage can become embedded in child development through inflammation, and deprivation is overrepresented in preterm… Show more

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