“…Hyper-or hypomethylation of DNA may induce the development of tumors by regulating their components, such as proteins of the extracellular matrix, and it can cause chromosomal instability (Dawson & Kouzarides, 2012;Sharma et al, 2010). Epigenetic alterations, isolated or combined, may be involved in the development and progress of SGT (Aniello et al, 2006;Augello et al, 2006;Binmadi et al, 2018;Daa et al, 2008;Durr et al, 2010;Ge et al, 2011;Guimarães et al, 2016;Hu et al, 2011;Kaira et al, 2013;Ling et al, 2016;Nikolic et al, 2018;Schache et al, 2010;Shao et al, 2011Shao et al, , 2012Stephens et al, 2013;Tan et al, 2014;Wagner et al, 2017;Wang et al, 2015;Williams et al, 2006;Xia et al, 2018Xia et al, , 2013Zhang et al, 2007Zhang et al, , 2014.…”