2016
DOI: 10.1016/j.jpsychires.2016.09.010
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Epigenetic signatures of childhood abuse and neglect: Implications for psychiatric vulnerability

Abstract: Childhood maltreatment is a key risk factor for poor mental and physical health. Recently, variation in epigenetic processes, such as DNA methylation, has emerged as a potential pathway mediating this association; yet, the extent to which different forms of maltreatment may be characterized by unique vs shared epigenetic signatures is currently unknown. In this study, we quantified DNA methylation across the genome in buccal epithelial cell samples from a high-risk sample of inner-city youth (n = 124; age = 16… Show more

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Cited by 105 publications
(79 citation statements)
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“…We then examined enriched biological pathways for genes that were associated with both phenotypes (i.e., “shared” pathways of ODD and ADHD). Using an optimized gene ontology method (see Cecil, Smith, et al., ) that controls for a range of potential confounds, including background probe distribution and gene size (see Table , for details), genes were considered “shared” if probes annotated to them were associated with both ODD and ADHD ( p < .001 consistently across both).…”
Section: Methodsmentioning
confidence: 99%
“…We then examined enriched biological pathways for genes that were associated with both phenotypes (i.e., “shared” pathways of ODD and ADHD). Using an optimized gene ontology method (see Cecil, Smith, et al., ) that controls for a range of potential confounds, including background probe distribution and gene size (see Table , for details), genes were considered “shared” if probes annotated to them were associated with both ODD and ADHD ( p < .001 consistently across both).…”
Section: Methodsmentioning
confidence: 99%
“…CCDC85, PTPRN) . More recently, based on a cross‐sectional sample of high‐risk youth (buccal cells; n = 124; age range = 16–24), we sought to characterise the DNAm ‘signatures’ of different forms of maltreatment, using an epigenome‐wide approach (Cecil, Smith, et al., ). We found that physical maltreatment showed the strongest associations with DNAm, implicating multiple genes previously associated with psychiatric and physical disorders (e.g.…”
Section: Environmental Risk Exposure and Dnam: The A Pathmentioning
confidence: 99%
“…The recent advancement in epigenome‐wide analyses has advanced the field beyond a gene‐candidate approach towards a more comprehensive mapping of the neuroepigenome. In this regard, life exposure‐ and phenotype‐specific epigenome signatures are constantly being generated, as in the case of childhood maltreatment, MDD, BD, SCZ, autism spectrum disorder, eating disorders and shared features, such as suicidality or psychosis . These epigenomic studies have uncovered dysregulation of multiple biological pathways, including the previously identified HPA, monoaminergic, and neurotrophin systems.…”
Section: Potential Use Of Epigenetics For Mechanistic Insight and Novmentioning
confidence: 99%