Epigenetic status of subtelomere of peripheral leukocytes corresponds to cardiographic parameters with a sex association

Maeda, Takeshi; Horiuchi, Takahiko; Makino, Naoki

doi:10.1111/ggi.13472

Cited by 6 publications

(3 citation statements)

References 23 publications

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“…In hypertensive patients, the degree of subtelomeric methylation of long telomeres was often inversely correlated with telomere consumption (Maeda et al, 2011b). Researchers found that cardiac function was related to both telomere length and subtelomeric DNA methylation (Maeda et al, 2018). Maeda et al (2013) also found that subtelomeres were hypomethylated and telomerase activity was decreased in senescent smooth muscle cells.…”

Section: Cardiovascular and Cerebrovascular Diseasesmentioning

confidence: 99%

“…Cardiovascular and cerebrovascular diseases are common diseases that seriously threaten the health of humans, especially middle-aged and elderly people. Previous studies have shown that cardiovascular and cerebrovascular diseases were significantly associated with subtelomeric DNA methylation and telomere length (Maeda et al, 2011b, 2018). In the future, subtelomeric DNA methylation should be investigated in other cardiovascular and cerebrovascular diseases (such as coronary heart disease, myocardial infarction, stroke, and etc.…”

Section: Cardiovascular and Cerebrovascular Diseasesmentioning

confidence: 99%

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The Alteration of Subtelomeric DNA Methylation in Aging-Related Diseases

Duan

2019

Front. Genet.

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The telomere is located at the end of the chromosome and consists of a non-coding, repetitive DNA sequence. As the cell divides, the length of telomere gradually decreases. A very short telomere can terminate mitosis, and thus telomere length becomes a hallmark of cellular aging. The 500 kb region of each autosomal arm terminal is the so-called subtelomeric region. Both telomere and subtelomere have high-density DNA repeats. Telomeres do not contain genes or CpG sequences, while subtelomeres contain small amounts of genes and high-density CpG sequences, and DNA methylation often occurs in subtelomeres. Previous studies have shown that aberrant methylation of subtelomeric DNA exists in many diseases, and it has a certain effect on the regulation of telomere length. In this review, we focus on the correlation between subtelomeric DNA methylation and aging-related diseases. We also summarize the relationship between subtelomeric methylation and telomere length in different diseases.

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Section: Cardiovascular and Cerebrovascular Diseasesmentioning

confidence: 99%

Section: Cardiovascular and Cerebrovascular Diseasesmentioning

confidence: 99%

The Alteration of Subtelomeric DNA Methylation in Aging-Related Diseases

Duan

2019

Front. Genet.

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“…Another study in 222 Japanese patients presenting with several predominantly chronic neurologic conditions investigated ECG measures in relation to semi-quantitatively measured telomere length using Southern blot analysis. The authors report an association with ECG measures including PR-interval, QRS-duration, and QTc [ 28 ]. Importantly, both studies did not adjust for age.…”

Section: Discussionmentioning

confidence: 99%

Common electrocardiogram measures are not associated with telomere length

Falkenhausen

Freudling

Waldenberger

et al. 2022

Aging

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Aims: Aging is accompanied by telomere shortening. Increased telomere shortening is considered a marker of premature aging. Cardiac aging results in the development of cardiac pathologies. Electrocardiogram (ECG) measures reflect cardiac excitation, conduction, and repolarization. ECG measures also prolong with aging and are associated with cardiac pathologies including atrial fibrillation. As premature prolongation of ECG measures is observed, we hypothesized that such prolongation may be associated with telomere length. Methods and Results: We studied the large, community-based KORA F4 Study. Of 3,080 participants enrolled between 2006 and 2007 with detailed information on demographic, anthropometric, clinical, and ECG characteristics, 2,575 presented with available data on leukocyte telomere length. Telomere length was determined by real-time quantitative PCR and expressed relative to a single copy gene. We fitted multivariable adjusted linear regression models to associate the ECG measures RR-interval, PR-interval, QRS-duration, and heart rate corrected QTc with telomere length. In our cohort, the mean age was 54.9±12.9 years and 46.6% were men. Increased age was associated with shorter telomere length (p<0.01), and men had shorter telomere length than women (p<0.05). In unadjusted models, heart rate (p=0.023), PR-interval (p<0.01), and QTc-interval (p<0.01) were significantly associated with shorter telomere length. However, no significant associations remained after accounting for age, sex, and covariates. Conclusions: ECG measures are age-dependent, but not associated with shortened telomere length as a marker of biological aging. Further research is warranted to clarify if shortened telomeres are associated with clinical cardiac pathologies including atrial fibrillation.

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