Epigenetic targets for therapeutic approaches in COPD and asthma. Nutrigenomics &amp;ndash; possible or illusive

Cherneva, Radostina; Kostadinov, Dimitar

doi:10.3897/folmed.61.e39160

Cited by 7 publications

(7 citation statements)

References 98 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Anti-miRNA molecules are small interfering oligonucleotides that bind to the target miRNA and prevent them from being processed by the RNA-induced silencing complex (RISC). miRNA mimetics are made of two strands and restore the function of their endogenous counterpart [53]. Below, the results of some of the latest publications revealing yet unknown pathways involved in the development of asthma are presented.…”

Section: Mirnas and Pathways Responsible For The Development Of Asthm...mentioning

confidence: 99%

miRNAs as Modern Biomarkers in Asthma Therapy

Kierbiedź-Guzik¹,

Sozańska

2023

IJMS

View full text Add to dashboard Cite

Asthma is a chronic inflammatory disease of the airways characterized by shortness of breath, chest tightness, coughing, and wheezing. For several decades (approximately 30 years), miRNAs and their role in asthma have been of constant interest among scientists. These small, non-coding RNA fragments, 18–25 nucleotides long, regulate gene expression at the post-transcriptional level by binding to the target mRNA. In this way, they affect several biological processes, e.g., shaping airway structures, producing cytokines and immune mediators, and controlling defense mechanisms. Publications confirm their potential role in the diagnosis and monitoring of the disease, but only some articles address the use of miRNAs in the treatment of asthma. The following paper reviews the latest available studies and presents miRNAs as a useful tool for predicting the effectiveness of the included treatment, early diagnosis of exacerbations, and in assessing patient compliance for different groups of drugs used in asthma. The latest known pathways underlying the pathogenesis of the disease, which are associated with a change in miRNA expression, may be precise targets of therapeutic activity in the future.

show abstract

Section: Mirnas and Pathways Responsible For The Development Of Asthm...mentioning

confidence: 99%

miRNAs as Modern Biomarkers in Asthma Therapy

Kierbiedź-Guzik¹,

Sozańska

2023

IJMS

View full text Add to dashboard Cite

show abstract

“…It also activates the expression of antioxidant genes, giving it anti-inflammatory properties. Catechins (found in green tea extract), garcinol (from kokum or Garcinia indica), and anacardic acid (derived from cashew nuts) also prevent NF-κB acetylation and are anti-inflammatory (42).…”

Section: Asthmamentioning

confidence: 99%

Nutrigenomics in Lifestyle Disorders: A Review

et al. 2022

View full text Add to dashboard Cite

In the era of increasing unhealthy dietary and lifestyle habits, maintaining a healthy diet is really important to prevent a broad spectrum of diseases. Lifestyle diseases occur due to certain unhealthy daily habits (smoking, unhealthy diet, and physical inactivity) that lead to inappropriate relationships with the environment. The consumption of food in an improper quantity and lacking in quality can have adverse effects on an individual’s health. Diet can bring about certain changes in genes which can be studied in the areas of nutrigenomics, nutrigenetics, epigenetics, epigenomics, and transcriptomics. This can help us understand how genetic makeup responds to nutrition in terms of transcription and translation processes. In this review, the effect of nutrition on gene expressions related to lifestyle disorders such as metabolic syndrome, CVD, and asthma is discussed.

show abstract

“…Another bioactive compound, diferuloylmethane, is also capable of inducing epigenetic regulation and contributing to lung health. Known as curcumin or turmeric from India, this compound has a pleiotropic role, interacting with several molecular targets, such as transcription factors, proteins and enzymes associated with epigenetic modulations ( 208 ). By acting in the regulation of histone protein acetylation/deacetylation processes, it promotes changes in chromatin structure, which can influence inflammatory responses.…”

Section: Bioactive Compounds and Epigenetic Regulation In Lung Healthmentioning

confidence: 99%

“…The safe dose of curcumin is 12 grams per day; however, there are few clinical studies that have shown that ingesting curcumin can have anti-inflammatory effects, considering that one of its main disadvantages is its low bioavailability and hydrophobic nature ( 208 ).…”

Section: Bioactive Compounds and Epigenetic Regulation In Lung Healthmentioning

confidence: 99%

“…Moreover, it is also able to prevent the binding of p300. Its anti-inflammatory effect is mediated by inhibition of p300-mediated acetylation with the NK-κB promoter ( 208 ). It is described that ingestion through catechin feeding is able to improve lung health and to reduce shortness of breath and sputum in COPD ( 215 ).…”

Section: Bioactive Compounds and Epigenetic Regulation In Lung Healthmentioning

confidence: 99%

See 1 more Smart Citation

Immunomodulatory Role of Nutrients: How Can Pulmonary Dysfunctions Improve?

et al. 2021

View full text Add to dashboard Cite

Nutrition is an important tool that can be used to modulate the immune response during infectious diseases. In addition, through diet, important substrates are acquired for the biosynthesis of regulatory molecules in the immune response, influencing the progression and treatment of chronic lung diseases, such as asthma and chronic obstructive pulmonary disease (COPD). In this way, nutrition can promote lung health status. A range of nutrients, such as vitamins (A, C, D, and E), minerals (zinc, selenium, iron, and magnesium), flavonoids and fatty acids, play important roles in reducing the risk of pulmonary chronic diseases and viral infections. Through their antioxidant and anti-inflammatory effects, nutrients are associated with better lung function and a lower risk of complications since they can decrease the harmful effects from the immune system during the inflammatory response. In addition, bioactive compounds can even contribute to epigenetic changes, including histone deacetylase (HDAC) modifications that inhibit the transcription of proinflammatory cytokines, which can contribute to the maintenance of homeostasis in the context of infections and chronic inflammatory diseases. These nutrients also play an important role in activating immune responses against pathogens, which can help the immune system during infections. Here, we provide an updated overview of the roles played by dietary factors and how they can affect respiratory health. Therefore, we will show the anti-inflammatory role of flavonoids, fatty acids, vitamins and microbiota, important for the control of chronic inflammatory diseases and allergies, in addition to the antiviral role of vitamins, flavonoids, and minerals during pulmonary viral infections, addressing the mechanisms involved in each function. These mechanisms are interesting in the discussion of perspectives associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and its pulmonary complications since patients with severe disease have vitamins deficiency, especially vitamin D. In addition, researches with the use of flavonoids have been shown to decrease viral replication in vitro. This way, a full understanding of dietary influences can improve the lung health of patients.

show abstract

Epigenetic targets for therapeutic approaches in COPD and asthma. Nutrigenomics – possible or illusive

Cited by 7 publications

References 98 publications

miRNAs as Modern Biomarkers in Asthma Therapy

miRNAs as Modern Biomarkers in Asthma Therapy

Nutrigenomics in Lifestyle Disorders: A Review

Immunomodulatory Role of Nutrients: How Can Pulmonary Dysfunctions Improve?

Contact Info

Product

Resources

About