2024
DOI: 10.1172/jci183391
|View full text |Cite
|
Sign up to set email alerts
|

Epigenetic therapies targeting histone lysine methylation: complex mechanisms and clinical challenges

Sarah Gold,
Ali Shilatifard

Abstract: As epigenetic therapies continue to gain ground as potential treatment strategies for cancer and other diseases, compounds that target histone lysine methylation and the enzyme complexes represent a major frontier for therapeutic development. Clinically viable therapies targeting the activities of histone lysine methyltransferases (HKMT) and demethylases (HKDMs) have only recently begun to emerge following FDA approval of the EZH2 inhibitor tazemetostat in 2020 and remain limited to compounds targeting the wel… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

0
0
0

Year Published

2024
2024
2024
2024

Publication Types

Select...
1

Relationship

0
1

Authors

Journals

citations
Cited by 1 publication
references
References 116 publications
0
0
0
Order By: Relevance