Epigenetic Treatments for Cognitive Impairments

Day, Jeremy J.; Sweatt, J. David

doi:10.1038/npp.2011.85

Cited by 110 publications

(63 citation statements)

References 156 publications

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“…Around 350 million people are affected by depression globally [1], and in Europe, depression affects 6.9% of the population [2]. WHO estimates that the burden of unipolar major depression will be the largest global cause for disability-adjusted life years in 2030 [3]. These figures highlight the challenges for healthcare systems, for professionals' clinical competence and first of all for people suffering from depressive symptoms [4].…”

Section: Introductionmentioning

confidence: 99%

Applicability of acceptance and commitment therapy-based mobile app in depression nursing

Kaipainen¹,

Välkkynen²,

Kilkku

2016

Behav. Med. Pract. Policy Res.

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Due to the high burden of depression, new models and methods of mental healthcare need to be developed. Prior research has shown the potential benefits of using technology tools such as mobile apps as self-help or combined with psychological treatment. Therefore, professionals should acquaint themselves with evidence-based apps to be able to use them with clients and guide the clients in their use. The purpose of this study was to explore how an acceptance and commitment therapy-based mobile app was perceived as a self-management tool among nurses, and how it could be applied in the prevention and treatment of depression and other mental health issues. Sixteen Finnish nurses undergoing depression nurse specialist education used the app for 5 weeks and participated in semistructured focus group interviews. Interviews were analyzed by qualitative content analysis. In general, the nurses found the app suitable as a self-management tool and identified three models of using it in clinical practice. Having used the app personally, the nurses were eager to take it into use with various client groups, especially in occupational health but also in the treatment of mental health problems. However, they also raised concerns about the effort needed in familiarizing oneself with the content and pointed out specific client groups for whom the benefits of the app should be carefully weighed against the potential risks. Despite the small sample size, the findings suggest that involving technology tools as part of the nurses' education could ease their adoption in clinical practice. The degree of professional support in the app use should be aligned to the severity of the mental health problems.

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Section: Introductionmentioning

confidence: 99%

Applicability of acceptance and commitment therapy-based mobile app in depression nursing

Kaipainen¹,

Välkkynen²,

Kilkku

2016

Behav. Med. Pract. Policy Res.

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“…Several drugs that are already well accepted for treatment of depression seem to engage epigenetic mechanisms, specifically HPTMs (Tsankova et al, 2006;Covington et al, 2009). To date, most psychiatric diseases or their corresponding animal models have been linked to epigenetic dysregulation (Graff and Mansuy, 2009;Ptak and Petronis, 2010;Day and Sweatt, 2012), and thus we expect that the next years will bring major advances in the contribution of epigenetic mechanisms to disease etiology. One key point will be to understand how epigenetic marks can be induced or manipulated at specific target sites with tissue or even cell-type specificity.…”

Section: Small Noncoding Rnas In Spermmentioning

confidence: 99%

Epigenetic Inheritance of Disease and Disease Risk

Bohacek

Mansuy

2012

Neuropsychopharmacol

151

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Epigenetic marks in an organism can be altered by environmental factors throughout life. Although changes in the epigenetic code can be positive, some are associated with severe diseases, in particular, cancer and neuropsychiatric disorders. Recent evidence has indicated that certain epigenetic marks can be inherited, and reshape developmental and cellular features over generations. This review examines the challenging possibility that epigenetic changes induced by environmental factors can contribute to some of the inheritance of disease and disease risk. This concept has immense implications for the understanding of biological functions and disease etiology, and provides potential novel strategies for diagnosis and treatment. Examples of epigenetic inheritance relevant to human disease, such as the detrimental effects of traumatic stress or drug/toxic exposure on brain functions, are reviewed. Different possible routes of transmission of epigenetic information involving the germline or germline-independent transfer are discussed, and different mechanisms for the maintenance and transmission of epigenetic information like chromatin remodeling and small noncoding RNAs are considered. Future research directions and remaining major challenges in this field are also outlined. Finally, the adaptive value of epigenetic inheritance, and the cost and benefit of allowing acquired epigenetic marks to persist across generations is critically evaluated.

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“…Given that MBD1 interacts with H3K9 methyltransferases to establish silent chromatin (4), we evaluated the expression of specific enzymes known as modifiers of this site-euchromatic histone lysine N-methyltransferase 2, SUV39H1 (Drosophila), SUV39H2, and SETDB1-in the offspring (9). Of the four enzymes tested, only SETDB1 showed higher mRNA levels in the HFD-C group than in the C-C group (n = 7, 1.7-fold, P = 0.039) (Fig.…”

Section: Maternal Chronic Hfd Consumption Has a Long-term Effect On Nmentioning

confidence: 99%

“…New evidence shows an interaction between DNA and histone modifications mediated through methyl-binding domain (MBD) proteins (9). The MBD proteins, namely MeCP2 and MBD1-4, bind to methylated CpG sequences and recruit enzymatic machinery such as histone deacetylases (HDACs), suppressor of variegation 3-9 homolog 1 (SUV39H1), and other chromatin-remodeling complexes affecting transcription regulators.…”

mentioning

confidence: 99%

DNA CpG Methylation (5-Methylcytosine) and Its Derivative (5-Hydroxymethylcytosine) Alter Histone Posttranslational Modifications at the Pomc Promoter, Affecting the Impact of Perinatal Diet on Leanness and Obesity of the Offspring

et al. 2016

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A maternal high-fat diet (HFD) alters the offspring's feeding regulation, leading to obesity. This phenomenon is partially mediated by aberrant expression of the hypothalamic anorexigenic neuropeptide proopiomelanocortin (POMC). Nevertheless, although some individual offspring suffer from morbid obesity, others escape the malprogramming. It is suggested that this difference is due to epigenetic programming. In this study, we report that in lean offspring of non-HFD–fed dams, essential promoter regions for Pomc expression were enriched with 5-hydroxymethylcytosine (5hmC) together with a reduction in the level of 5-methylcytosine (5mC). Moreover, 5hmC was negatively correlated whereas 5mC was positively correlated with body weight in offspring from both HFD- and control-fed dams. We further found that Pomc expression in obese offspring is determined by a two-step epigenetic inhibitory mechanism in which CpG methylation is linked with histone posttranslational modifications. An increase in CpG methylation at the Poxmc promoter enables binding of methyl-binding domain 1 (MBD1) to 5mC, but not to its derivative 5hmC. MBD1 then interacts with SET domain bifurcated 1 methyltransferase to promote bimethylation on the histone 3 lysine 9 residue, reducing Pomc mRNA expression. These results suggest an epigenetic regulatory mechanism that affects obesity-prone or resilient traits.

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Epigenetic Treatments for Cognitive Impairments

Cited by 110 publications

References 156 publications

Applicability of acceptance and commitment therapy-based mobile app in depression nursing

Applicability of acceptance and commitment therapy-based mobile app in depression nursing

Epigenetic Inheritance of Disease and Disease Risk

DNA CpG Methylation (5-Methylcytosine) and Its Derivative (5-Hydroxymethylcytosine) Alter Histone Posttranslational Modifications at the Pomc Promoter, Affecting the Impact of Perinatal Diet on Leanness and Obesity of the Offspring

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