Epigenetically dysregulated NOTCH-Delta-HES signaling cascade can serve as a subtype classifier for acute lymphoblastic leukemia

Hussan, Syeda Saliah; Ali, Muhammad Shrafat; Fatima, Mishal; Altaf, Memoona; Sadaf, Saima

doi:10.1007/s00277-023-05515-9

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Cited by 2 publications

References 43 publications

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Immune-related gene methylation prognostic instrument for stratification and targeted treatment of ovarian cancer patients toward advanced 3PM approach

Jia,

Li,

Wang

et al. 2024

EPMA Journal

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Immune-related gene methylation prognostic instrument for stratification and targeted treatment of ovarian cancer patients toward advanced 3PM approach

Jia,

Li,

Wang

et al. 2024

EPMA Journal

View full text Add to dashboard Cite

Expression status transition ofNOTCH1accompanies chromatin remodeling in human early retinal progenitor cells

Nakayama

Yoshihara

Takahashi

2023

Preprint

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Notch signaling-mediated differentiation is dependent on the fine-tuned expression regulation. Especially, the diversification processes of the initially homogenous undifferentiated cells were well-documented for this signaling pathway. Although this signaling pathway is involved in the development of mammalian retina, for example, it is unclear how the expression levels of the Notch signaling components were regulated. Here, we analyzed the publicly available datasets of single-cell RNA-seq and single-cell ATAC-seq from human fetus retina at days 53, 59 and 78 to examine the status of the mRNA expressions and chromatin accessibilities of the Notch signaling components. We found that Notch signaling components were expressed in the undifferentiated cells and that the chromatin accessibilities in those cells were different among themselves. This finding revealed the epigenetic heterogeneity among the differentiating cells during Notch signaling-driven cellular dynamics.

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Epigenetically dysregulated NOTCH-Delta-HES signaling cascade can serve as a subtype classifier for acute lymphoblastic leukemia

Cited by 2 publications

References 43 publications

Immune-related gene methylation prognostic instrument for stratification and targeted treatment of ovarian cancer patients toward advanced 3PM approach

Immune-related gene methylation prognostic instrument for stratification and targeted treatment of ovarian cancer patients toward advanced 3PM approach

Expression status transition ofNOTCH1accompanies chromatin remodeling in human early retinal progenitor cells

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