Epigenetics and its implications for oral health

Singh, Amarjot; Gill, Gurveen; Jakhu, Harpal

doi:10.1016/j.job.2018.02.001

Cited by 7 publications

(4 citation statements)

References 69 publications

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“…It should be noted that this association goes in both ways, that is, the mouth being a system within another more complex system, changes in the body, mind and emotions also generate alterations in oral health (39)(40)(41)(42)(43)(44)(45)(46).…”

Section: Towards a Model For Holistic Health Through The Oral Cavitymentioning

confidence: 99%

“…This is of great importance, since salivary proteins support the ecology of the oral cavity, increase the defensive mechanisms in the mouth, determine the chemical and physical properties of saliva (such as viscosity and lubrication), in addition to having special functions not only for the health of the oral cavity but also for microorganisms, including nutrition, survival and colonization as well as for the adhesion and aggregation of microorganisms; and at the same time fluoride in saliva is essential for the balance between demineralization and remineralization of enamel. Therefore, the changes generated by stress in saliva increase susceptibility to oral diseases, particularly the progression of dental caries ( 45 ).…”

Section: The Mouth and Its Importance For Well-beingmentioning

confidence: 99%

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Your health is in your mouth: A comprehensive view to promote general wellness

Barranca-Enríquez

Romo‐González

2022

Front. Oral. Health

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BackgroundEven though various studies recognize the importance of the oral cavity to have general health, in multidisciplinary professional practice it is almost always excluded and on an individual basis, very commonly neglected. Oral diseases are preventable, still, they are highly prevalent. Although some studies consider oral health within integral health, currently, there is no model in which the mouth is integrated within other levels for the achievement of well-being. The objective of this article was to review the importance of oral health and its connection with well-being and, based on these findings, propose a complex and comprehensive perspective for approach and care.MethodsThe databases MEDLINE, PubMed, and Google Scholar were revised for randomized controlled trials and reviews that included search terms related to oral health and its relationship with the general health in its different levels (physical, psychological, social and environmental).ResultsThe review shows that oral health is critical, as the teeth and mouth are not only an integral part of the body, but also, they also support and enable essential human functions. That is, oral health has a multidimensional nature, as it includes the physical, psychological, social, and environmental domains that are essential for overall health and well-being. Likewise, the mouth is the psychological seat of the first physiological needs and emotional gratifications, with it we take a taste of the world around us. Thus, the mouth plays an important role in the feeling of unity and in the constitution of the self. Based on these results we propose an integrative model in which the mouth is the first step for well-being and from this integrative model we build a multidisciplinary approach which could be used in the clinical practice for the promotion of oral care and general health.ConclusionThe effort on the part of oral health professionals is essential for people's well-being and must be integrated as part of health promotion. Dental treatments alone cannot solve this problem, it requires a comprehensive and approach in which the bio-psychological, behavioral, and socio-environmental determinants are included to face this global oral health challenge. That is, without a comprehensive and multidisciplinary approach to medical science that includes dental and oral health, our public policies cannot provide the best answers to health promotion, disease prevention, early detection, and treatment.

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Section: Towards a Model For Holistic Health Through The Oral Cavitymentioning

confidence: 99%

Section: The Mouth and Its Importance For Well-beingmentioning

confidence: 99%

Your health is in your mouth: A comprehensive view to promote general wellness

Barranca-Enríquez

Romo‐González

2022

Front. Oral. Health

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“…As for the population aged 65-74, the total tooth loss rate is as high as nearly 30% [27]. The concept of oral health has gradually increased with the increase of the number of elderly people and the aging of society [28], [29]. Oral diseases have become an important public health problem and promoted the continuous development and progress of global oral medicine technology [24], [30].…”

Section: Introductionmentioning

confidence: 99%

Registration Technology of Augmented Reality in Oral Medicine: A Review

et al. 2019

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Augmented reality (AR) technology, as a computer simulation technology, combines various technologies such as virtual reality, computer vision, computer network, and human-computer interaction. AR has been widely used in medicine. The introduction of AR can effectively help the doctors to complete preoperative planning, intraoperative guidance, postoperative evaluation, and medical training. Oral medicine is a major branch of modern medicine. AR can enhance the doctor's visual system, making the internal structure of the oral clearer and effectively reducing the difficulty of oral repair/surgery. Real-time tracking, registration, display, and interactive technologies for AR will play an important role in oral medicine. Among them, registration technology has become an important indicator for evaluating the AR system, and it is also the main bottleneck restricting the stability and applicability of the current AR system. Therefore, we reviewed the registration technology of AR in oral medicine. First, we conducted a hot spot analysis of AR keywords based on Citespace. And then, the registration technology is divided into static registration and real-time registration according to the actual clinical application, among which static registration is divided into rigid registration and non-rigid registration. We discussed problems and limitations of static registration and real-time registration in oral applications at this stage. Finally, the future direction of AR registration technology in oral medicine is proposed.

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“…Several genes are involved in the carcinogenesis process, and they are reported elsewhere. The most common causes of cancer are epimutations, where environmental pollutions are the main players [8,9]. Epigenetics is a kind of non-sequence dependent inheritance, where a change in the DNA methylation, histone modification, among others, might cause cancer to develop [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Cancer Epigenetics: Shifting to More Deep Action

Sabit

Abdel-Ghany

Çevik

et al. 2019

NACS

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Cancer is a major health problem facing the entire human population. It affects almost every race, gender, or age in the social hierarchy. Many mechanisms have been proposed for the development of cancer; either genetic or epigenetic. Over the years, a cumulative body of research indicated that epigenetic mutations (epimutations) represent a chief player in the course of cancer, where it affects cell proliferation, cancer initiation, progression, apoptosis, and metastasis. In this minireview we highlight the main mechanisms of epigenetic-mediated cancer development with emphasis on the environmental pollution role in this arena.

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Epigenetics and its implications for oral health

Cited by 7 publications

References 69 publications

Your health is in your mouth: A comprehensive view to promote general wellness

Your health is in your mouth: A comprehensive view to promote general wellness

Registration Technology of Augmented Reality in Oral Medicine: A Review

Cancer Epigenetics: Shifting to More Deep Action

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