Epigenetics and periodontal disease: future perspectives

Gomez, Ricardo Santiago; Dutra, Walderez Ornelas; Moreira, Paula Rocha

doi:10.1007/s00011-009-0041-7

Cited by 56 publications

(60 citation statements)

References 43 publications

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“…Periodontitis is a multifactorial infection characterized by inflammation and destruction of tooth-supporting tissues (Gomez et al, 2009). The levels of prostaglandin E and the prostaglandin-endoperoxide synthase-2 (PTGS2) increase in progressing periodontal lesions, but decrease in chronic disease.…”

Section: Epigenetics In Human Diseases and Agingmentioning

confidence: 99%

Epigenetic Mechanisms in Inflammation

2010

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Epigenetic modifications occur in response to environmental changes and play a fundamental role in gene expression following environmental stimuli. Major epigenetic events include methylation and acetylation of histones and regulatory factors, DNA methylation, and small non-coding RNAs. Diet, pollution, infections, and other environmental factors have profound effects on epigenetic modifications and trigger susceptibility to diseases. Despite a growing body of literature addressing the role of the environment on gene expression, very little is known about the epigenetic pathways involved in the modulation of inflammatory and anti-inflammatory genes. This review summarizes the current knowledge about epigenetic control mechanisms during the inflammatory response.

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Section: Epigenetics In Human Diseases and Agingmentioning

confidence: 99%

Epigenetic Mechanisms in Inflammation

2010

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“…Review of Literature: Gomez et al conducted a review to show evidence that supports the hypothesis that epigenetic alteration, such as hyper and hypomethylation of cytokine genes could help to understand the mechanisms related to periodontal disease activity [5]. Therefore, epigenetics may have future impact on diagnosis and/or therapeutics of periodontal disease.…”

Section: Epigenetics In Dentistrymentioning

confidence: 99%

Epigenetics in Dentistry: A Literature Review

Mohsin¹,

Barshaik.²

2017

J Clin Epigenet

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“…The changes in gene expression, which are different from the ones in the primary DNA sequence, are the subject of epigenetics (15). Epigenetic changes appear without a direct change in the genetic sequence and can be reversible.…”

Section: • Link Between Rheumatoid Arthritis and Microorganismsmentioning

confidence: 99%

Chronic periodontitis and rheumatoid arthritis – microbiological aspects

Popova¹,

Panchovska²

2015

MedInform

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An overview of the literature on the role of periodontopathogenic microorganisms and chronic periodontitis in the emergence and development of rheumatoid arthritis is presented. The paper discusses the microbiological and genetic factors, environmental factors and the pathogenesis of the two diseases and presents evidence for the relationship between them. Porphyromonas gingivalis, associated with the severity of chronic periodontitis is the only microorganism documented to produce peptidylarginine deiminase (PAD), involved in the process of citrullination. P. gingivalis infection may generate citrullinated peptides, which trigger anti-cyclic citrullinated peptide (anti-CCP) antibodies against synovial lining of the joints. Citrullination by human PADs is important in normal physiology and inflammation. Porphyromonas gingivalis has not been detected in all investigated patients with rheumatoid arthritis and hasn`t been associated with the titer of rheumatoid factor / anti-cyclic citrullinated peptide (anti-CCP) antibodies. Probably in the process of citrullination another microorganism that will be shown in future studies takes an active role. The emphasis is placed on Anaeroglobus geminatus, which is associated with the titer of rheumatoid factor / anti-CCP antibodies and detected in all patients studied. The presence of Leptotrichia and Prevotella spp. only in patients with new-onset rheumatoid arthritis is highlighted.

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Epigenetics and periodontal disease: future perspectives

Cited by 56 publications

References 43 publications

Epigenetic Mechanisms in Inflammation

Epigenetic Mechanisms in Inflammation

Epigenetics in Dentistry: A Literature Review

Chronic periodontitis and rheumatoid arthritis – microbiological aspects

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