2018
DOI: 10.1111/1471-0528.15240
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Epigenetics and Reproductive Medicine

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Cited by 24 publications
(14 citation statements)
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References 129 publications
(199 reference statements)
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“…Superovulation, or controlled ovarian stimulation, involves the administration of exogenous gonadotropins to stimulate oocyte growth and is ubiquitous in IVF. Epigenetic establishment in oocytes occurs in a growth and maturation dependent manner, and superovulation has been hypothesized to interfere with this process by altering the timeline of development, recruitment of low quality oocytes or affecting enzymes required for appropriate epigenetic programming [107,108]. It is therefore unsurprising that superovulation has shown an effect on epigenetic regulation in both murine and human studies.…”
Section: In Vitro Fertilization/ Intracytoplasmic Sperm Injectionmentioning
confidence: 99%
“…Superovulation, or controlled ovarian stimulation, involves the administration of exogenous gonadotropins to stimulate oocyte growth and is ubiquitous in IVF. Epigenetic establishment in oocytes occurs in a growth and maturation dependent manner, and superovulation has been hypothesized to interfere with this process by altering the timeline of development, recruitment of low quality oocytes or affecting enzymes required for appropriate epigenetic programming [107,108]. It is therefore unsurprising that superovulation has shown an effect on epigenetic regulation in both murine and human studies.…”
Section: In Vitro Fertilization/ Intracytoplasmic Sperm Injectionmentioning
confidence: 99%
“…There is further evidence that ART can induce epigenetic variation that might be transmitted to the next generation and that subfertility itself is a risk factor for imprinting diseases (Huntriss et al, 2018). With more than 3000 twin-pairs and 200 triplet sets being born after various techniques of ART, whether born after fertility treatment without further intervention (ovulation induction only) or after IVF/ICSI or related techniques, EFPTS is the ideal resource for the long-term follow-up study of these multiples on a populationbased manner.…”
Section: Discussionmentioning
confidence: 99%
“…Several studies report increased rates of fetal growth restriction, low birthweight, prematurity, increased cardiovascular malformations, leukemia and Hodgkin lymphoma in ART offspring. With some studies indicating there can be metabolic effects in the long-term health of these children with increased incidences of elevated blood pressure, total body fat and fasting glucose being reported [121][122][123][124][125][126][127] Based on Green et al; 116 Critchley et al; 117 Critchley et al; 118 NICE; 119 Metzger et al; 120 Basu et al; 113 Davies et al; 121 Pinborg et al; 122 Huntriss et al; 123 Hart et al; 124 Giorgione et al; 125 Källén et al; 126 Reigstad et al 127…”
Section: Congenital Abnormalitiesmentioning
confidence: 99%
“… Based on Green et al; Critchley et al; Critchley et al; NICE; Metzger et al; Basu et al; Davies et al;, Pinborg et al; Huntriss et al; Hart et al; Giorgione et al; Källén et al; Reigstad et al …”
Section: Cancer and Pregnancyunclassified