Epigenetics and the role of nutraceuticals in health and disease

El-Sayed, Amr; Aleya, Lotfi; Kamel, Mohamed S.

doi:10.1007/s11356-023-25236-w

Cited by 2 publications

(1 citation statement)

References 296 publications

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“…In addition, the microbiome impacts host epigenetic regulation, modifying gene expression patterns without altering DNA sequences. Microbial metabolites and components can influence enzymes involved in DNA methylation and histone modification, altering gene expression profiles in host cells [1,[82][83][84][85][86]. These epigenetic changes affect immune responses, inflammation, and susceptibility to infectious diseases.…”

Section: Mechanisms Of Microbiome-mediated Pathogenesismentioning

confidence: 99%

Microbiome Dynamics: A Paradigm Shift in Combatting Infectious Diseases

Kamel,

Aleya,

Alsubih

et al. 2024

JPM

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Infectious diseases have long posed a significant threat to global health and require constant innovation in treatment approaches. However, recent groundbreaking research has shed light on a previously overlooked player in the pathogenesis of disease—the human microbiome. This review article addresses the intricate relationship between the microbiome and infectious diseases and unravels its role as a crucial mediator of host–pathogen interactions. We explore the remarkable potential of harnessing this dynamic ecosystem to develop innovative treatment strategies that could revolutionize the management of infectious diseases. By exploring the latest advances and emerging trends, this review aims to provide a new perspective on combating infectious diseases by targeting the microbiome.

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Section: Mechanisms Of Microbiome-mediated Pathogenesismentioning

confidence: 99%

Microbiome Dynamics: A Paradigm Shift in Combatting Infectious Diseases

Kamel,

Aleya,

Alsubih

et al. 2024

JPM

Self Cite

View full text Add to dashboard Cite

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Pharmacological evaluation of Natural Sea Salt against doxorubicin induced cardiac toxicity via Gut Microbiome

Asar,

Nadeem,

Abbasi

et al. 2023

Preprint

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Cardiovascular complications including cardiac toxicity pose a major health threat worldwide. These complications can be handled by reducing the associated risk factors including diet. Gut microbiome is prominently associated with cardiovascular diseases. The present study demonstrates how the gut microbiota, under the effect of table salt and natural sea salt, modulates doxorubicin-induced cardiac toxicity. Experimental animals were divided into six groups (n = 6) as: Group I. Normal control (NC); Group II: table salt (0.3%) (NTS); Group III: natural sea salt (0.3%) (NSS.); Group IV: Doxorubicin-induced cardiac toxicity control (2mg/kg) (DC); Group V:DC + Table salt (0.3%) (DTS.); and Group VI: DC + Natural sea salt (0.3%) (DSS). CKMB, CRP, lipid profile was assayed in serum, GUT microbiota in stool, and histopathological variations in heart tissues were studied. Significant alterations were observed in the analytical values of blood parameters in the doxorubicin versus the normal control group. Also, a significant variation was observed in DTS and DSS groups for CKMB (p < 0.001), CRP (p < 0.01; p < 0.05), TC, TG, LDL (p < 0.0001) and HDL (p < 0.05, p < 0.01) respectively, when compared with DC group. Presence of gut microbes were identified in the stool samples. The population of Proteobacteria and Spirochetes were significantly lowered the DC group as compared to all other groups. However, the treatment with the sea salt increased the richness of this phylum to 36-fold, while table salt increased only by 9-fold. The change in microbial population is a direct marker for cardiac toxicity, which was highly prevented by sea salt as compared to table salt. Histopathological alterations in cellular architecture of the heart reflect a marked effect of the salts on it. Our observations suggest that a diet with natural sea salt demonstrated a significant protection to cardiac toxicity that may have initiated via inflammation after doxorubicin injury compared to the table salt.

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Epigenetics and the role of nutraceuticals in health and disease

Cited by 2 publications

References 296 publications

Microbiome Dynamics: A Paradigm Shift in Combatting Infectious Diseases

Microbiome Dynamics: A Paradigm Shift in Combatting Infectious Diseases

Pharmacological evaluation of Natural Sea Salt against doxorubicin induced cardiac toxicity via Gut Microbiome

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