2022
DOI: 10.1172/jci158446
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Epigenetics, DNA damage, and aging

Abstract: Over the course of a human lifespan, genome integrity erodes, leading to an increased abundance of several types of chromatin changes. The abundance of DNA lesions (chemical perturbations to nucleotides) increases with age, as does the number of genomic mutations and transcriptional disruptions caused by replication or transcription of those lesions, respectively. At the epigenetic level, precise DNA methylation patterns degrade, likely causing increasingly stochastic variations in gene expression. Similarly, … Show more

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Cited by 65 publications
(31 citation statements)
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“…Similarly, DNA damage play a role in inducing promoter methylation changes associated with cancer, and inhibiting this has antitumor effects [74]. Similar to genomic mutations and transcriptional disruptions that increase with aging, DNAm aberrations and altered histone modifications also increase, fostering stochastic variations in gene expression [75]. This increases the frequency of occurrence of spontaneous DNA lesions, prompting DNA damage response (DDR) to halt the cell cycle and enable DNA repair [76] (Fig.…”
Section: Dna Damagementioning
confidence: 99%
“…Similarly, DNA damage play a role in inducing promoter methylation changes associated with cancer, and inhibiting this has antitumor effects [74]. Similar to genomic mutations and transcriptional disruptions that increase with aging, DNAm aberrations and altered histone modifications also increase, fostering stochastic variations in gene expression [75]. This increases the frequency of occurrence of spontaneous DNA lesions, prompting DNA damage response (DDR) to halt the cell cycle and enable DNA repair [76] (Fig.…”
Section: Dna Damagementioning
confidence: 99%
“…The biological mechanism of aging remains one of the main mysteries in modern biology. Most scientists dealing with this problem agree in the opinion that aging is either the result of a purposeful evolutionary program inherent in the genome ( Larocca et al, 2021 ; De Magalhães Church., 2005 ; Bilinski et al, 2021 ), or a consequence of spontaneous disturbances in the organism leading to maladaptation ( Soto-Palma et al, 2022 ; Kinzina et al, 2019 ). At the same time both approaches to the causes of aging are not yet presented by the description of a specific mechanism explaining the emergence and acceleration of aging after reaching fertility ( Walker, 2022 ; West et al, 2019 ).…”
Section: Introductionmentioning
confidence: 99%
“…Aging is known to be tightly linked to many biological processes and pathways, some of which have been coined as the “hallmarks of aging” (Lopez‐Otin et al, 2013). One of the major pathways which is known to be involved in aging is epigenetic changes (Lopez‐Otin et al, 2023; Owczarz et al, 2020; Sikder et al, 2022; Singh et al, 2013; Soto‐Palma et al, 2022; Tennen et al, 2011; Yang et al, 2023).…”
Section: Introductionmentioning
confidence: 99%