Epigenetics in Alzheimer’s Disease: A Critical Overview

Villa, Chiara; Combi, Romina

doi:10.3390/ijms25115970

Cited by 3 publications

(1 citation statement)

References 132 publications

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“…[ 70 ] Novel discoveries, such as epigenetic changes and the identification of aging measures, are also emerging as effective markers for AD, thus expanding the scope of potential AD markers. [ 71 ] The screening of AD biomarkers still needs further in-depth study and more theoretical and practical basis.…”

Section: Discussionmentioning

confidence: 99%

Research progress on humoral biomarkers of Alzheimer’s disease: A review

Zhang,

Fu,

Yang

et al. 2024

Medicine

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Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by progressive memory loss. The main pathological features are neuronal fibrillary tangles caused by amyloid beta deposition and hyperphosphorylation of tau protein, accompanied by neuronal death and loss of synaptic structure. Early diagnosis is the key to the treatment of AD. It is known that some small molecular components are related to the pathogenesis of AD. This article will summarize the common AD biomarkers in cerebrospinal fluid and blood and analyze the current status of AD biomarkers and future research directions. This review summarizes the promising biomarkers for the diagnosis of AD in the last decade and describes their changes in AD body fluids. The diagnostic biomarkers related to AD were mainly distributed in cerebrospinal fluid and blood. Significant changes in these molecules can be detected in cerebrospinal fluid and blood, and they are correlated with AD severity. These humoral molecules have necessary relationship with AD and can be used as AD biomarkers to assist early diagnosis of AD.

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Section: Discussionmentioning

confidence: 99%

Research progress on humoral biomarkers of Alzheimer’s disease: A review

Zhang,

Fu,

Yang

et al. 2024

Medicine

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Epigenetic biomarkers in Alzheimer's disease: Diagnostic and prognostic relevance

Behl,

Kyada,

Roopashree

et al. 2024

Ageing Research Reviews

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Epigenetic Mechanisms in Aging: Extrinsic Factors and Gut Microbiome

Borrego-Ruiz,

Borrego

2024

Genes

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Background/Objectives: Aging is a natural physiological process involving biological and genetic pathways. Growing evidence suggests that alterations in the epigenome during aging result in transcriptional changes, which play a significant role in the onset of age-related diseases, including cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. For this reason, the epigenetic alterations in aging and age-related diseases have been reviewed, and the major extrinsic factors influencing these epigenetic alterations have been identified. In addition, the role of the gut microbiome and its metabolites as epigenetic modifiers has been addressed. Results: Long-term exposure to extrinsic factors such as air pollution, diet, drug use, environmental chemicals, microbial infections, physical activity, radiation, and stress provoke epigenetic changes in the host through several endocrine and immune pathways, potentially accelerating the aging process. Diverse studies have reported that the gut microbiome plays a critical role in regulating brain cell functions through DNA methylation and histone modifications. The interaction between genes and the gut microbiome serves as a source of adaptive variation, contributing to phenotypic plasticity. However, the molecular mechanisms and signaling pathways driving this process are still not fully understood. Conclusions: Extrinsic factors are potential inducers of epigenetic alterations, which may have important implications for longevity. The gut microbiome serves as an epigenetic effector influencing host gene expression through histone and DNA modifications, while bidirectional interactions with the host and the underexplored roles of microbial metabolites and non-bacterial microorganisms such as fungi and viruses highlight the need for further research.

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Epigenetics in Alzheimer’s Disease: A Critical Overview

Cited by 3 publications

References 132 publications

Research progress on humoral biomarkers of Alzheimer’s disease: A review

Research progress on humoral biomarkers of Alzheimer’s disease: A review

Epigenetic biomarkers in Alzheimer's disease: Diagnostic and prognostic relevance

Epigenetic Mechanisms in Aging: Extrinsic Factors and Gut Microbiome

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