Epigenetics in autoimmune diseases with focus on type 1 diabetes

Dang, Mary; Buzzetti, Raffaella; Pozzilli, Paolo

doi:10.1002/dmrr.2375

Cited by 77 publications

(39 citation statements)

References 107 publications

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“…The epigenetic markers such as miRNAs have been identified, which are beneficial for therapeutic interventions and early disease diagnosis [12]. The epigenetic mechanisms that regulate the gene transcription include histone modifications and noncoding RNAs and DNA methylation [13].…”

Section: Epigenetic Mechanismmentioning

confidence: 99%

Twin-Studies on the Role of Non-Genetic Factors in T1D Pathogenesis

Ma¹,

Wu²,

Dong³

et al. 2017

Proceedings of the 2nd International Conference on Biomedical and Biological Engineering 2017 (BBE 2017)

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Abstract. Type 1 diabetes (T1D) is a complex autoimmune disease characterized by T cell-mediated destruction of pancreatic β cells, which is resulted from the interaction of genetic and environmental factors. Twin-study is one of the most important methods to identify the genetic basis of complex diseases or traits as well as the influence of non-genetic factors in the pathogenesis of T1D. This article summarizes recent twin-studies about the role of non-genetic factors in T1D pathogenesis, including epigenetic mechanism, immunity, and complication factors. In addition, we discuss the potential necessity of the twin-study method in the research on the influence of the living environment on T1D.

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Section: Epigenetic Mechanismmentioning

confidence: 99%

Twin-Studies on the Role of Non-Genetic Factors in T1D Pathogenesis

Ma¹,

Wu²,

Dong³

et al. 2017

Proceedings of the 2nd International Conference on Biomedical and Biological Engineering 2017 (BBE 2017)

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“…Changes in DNA methylation patterns have been observed in association with CVD, inflammation, autoimmune diseases, infections and cancer [Bierne et al 2012;Dang et al 2013;Esteller, 2008].…”

Section: Dna Methylationmentioning

confidence: 99%

The emerging role of epigenetics in cardiovascular disease

Khalil

2014

Therapeutic Advances in Chronic Disease

110

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There is a worldwide epidemic of cardiovascular diseases causing not only a public health issue but also accounting for trillions of dollars of healthcare expenditure. Studies pertaining to epidemiology, pathophysiology, molecular biology, gene identification and genetic linkage maps have been able to lay a strong foundation for both the diagnosis and treatment of cardiovascular medicine. Although the concept of 'epigenetics' is not recent, the term in current usage is extended from the initial concept of 'controlling developmental gene expression and signaling pathways in undifferentiated zygotes' to include heritable changes to gene expression that are not from differences in the genetic code. The impact of epigenetics in cardiovascular disease is now emerging as an important regulatory key player at different levels from pathophysiology to therapeutics. This review focuses on the emerging role of epigenetics in major cardiovascular medicine specialties such as coronary artery disease, heart failure, cardiac hypertrophy and diabetes.

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“…Esta reacción es catalizada por las enzimas ADN metiltransferasas (DNMTs) y ocurre tanto a nivel global como a nivel gen-específico. Así, cuando regiones ricas en estos dinucleótidos CpG, están ubicadas en la región promotora de los genes, su metilación conduce al silenciamiento de dicho gen [14][15][16][17][18] . En un estudio realizado el año 2011 19 se identificaron 132 posiciones de metilación variables entre gemelos monocigotos discordantes (uno diabético tipo 1 diagnosticado antes de los 20 años y el otro sano).…”

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