Epigenetics in Epidemiology

Nicolini, Humberto; Genis‐Mendoza, Alma Delia; Martínez‐Magaña, José Jaime

doi:10.1007/978-3-030-89601-0_4

Cited by 1 publication

(1 citation statement)

References 134 publications

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“…Infectious diseases are currently one of the most explored fields for clinical and public health genomics, as sequencing technologies simplified and accelerated the deep characterization of pathogens ( 1 ). Pathogen genomics is transforming surveillance programs allowing both prompt identification of outbreaks and epidemics and accurate diagnosis at individual level, replacing the standard techniques in microbiology laboratories ( 2 , 3 ). The emergence of infectious threats, such as SARS-CoV-2 and Monkeypox viruses, showed the needs of strengthening health systems worldwide with implementation of NGS capacity ( 4 ).…”

Section: Introductionmentioning

confidence: 99%

Implementation of targeted next-generation sequencing for the diagnosis of drug-resistant tuberculosis in low-resource settings: a programmatic model, challenges, and initial outcomes

Araujo

Cabibbe

Mhuulu

et al. 2023

Front. Public Health

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Targeted next-generation sequencing (tNGS) from clinical specimens has the potential to become a comprehensive tool for routine drug-resistance (DR) prediction of Mycobacterium tuberculosis complex strains (MTBC), the causative agent of tuberculosis (TB). However, TB mainly affects low- and middle-income countries, in which the implementation of new technologies have specific needs and challenges. We propose a model for programmatic implementation of tNGS in settings with no or low previous sequencing capacity/experience. We highlight the major challenges and considerations for a successful implementation. This model has been applied to build NGS capacity in Namibia, an upper middle-income country located in Southern Africa and suffering from a high-burden of TB and TB-HIV, and we describe herein the outcomes of this process.

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