Epigenetics in Health and Disease

Zhang, Lian; Lu, Qianjin; Chang, Christopher

doi:10.1007/978-981-15-3449-2_1

Cited by 414 publications

(315 citation statements)

References 197 publications

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“…Epigenetic mechanisms including DNA methylation and chemical modifications of histone proteins like methylation, phosphorylation, ubiquitination, acetylation and ADP-ribosylation significantly contribute to the regulation of transcriptional gene activity. These modifications are key events which affect transcription factor binding to DNA and change the chromatin structure resulting either in gene activation or gene silencing [20]. Epigenetic gene regulation is important for the regulation of many biological processes, including embryogenesis, genomic imprinting or X chromosome inactivation [19,20].…”

Section: What Is Epigenetics?mentioning

confidence: 99%

“…These modifications are key events which affect transcription factor binding to DNA and change the chromatin structure resulting either in gene activation or gene silencing [20]. Epigenetic gene regulation is important for the regulation of many biological processes, including embryogenesis, genomic imprinting or X chromosome inactivation [19,20].…”

Section: What Is Epigenetics?mentioning

confidence: 99%

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DNA methylation as predictive marker of response to immunotherapy?

Heller

2021

memo

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Section: What Is Epigenetics?mentioning

confidence: 99%

Section: What Is Epigenetics?mentioning

confidence: 99%

DNA methylation as predictive marker of response to immunotherapy?

Heller

2021

memo

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“…( 105 - 108 ) The major epigenetic mechanisms include DNA methylation (DNAm), histone modification, and non-coding RNAs (ncRNAs). ( 109 , 110 ) DNAm, an addition of a methyl group to cytosines, occurs predominantly in cytosines located at 5’ of guanines (known as CpG dinucleotides). Although its function may vary, DNAm, when it occurs in promoter regions, generally is associated with gene silencing and repressing gene expression.…”

Section: Epigenetics: the Interface Of Genes And Environment In Mediating The Stress Responsementioning

confidence: 99%

Gaining a deeper understanding of social determinants of preterm birth by integrating multi-omics data

2020

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In the US, high rates of preterm birth (PTB) and profound Black-White disparities in PTB have persisted for decades. This review focuses on the role of social determinants of health (SDH), with an emphasis on maternal stress, in PTB disparity and biological embedding. It covers: 1) PTB disparity in US Black women and possible contributors; 2) The role of SDH, highlighting maternal stress, in the persistent racial disparity of PTB; 3) Epigenetics at the interface between genes and environment; 4) The role of the genome in modifying maternal stress-PTB associations; 5) Recent advances in multi-omics studies of PTB; and 6) Future perspectives on integrating multi-omics with SDH to elucidate the Black-White disparity in PTB. Available studies have indicated that neither environmental exposures nor genetics alone can adequately explain the Black-White PTB disparity. Preliminary yet promising findings of epigenetic and gene-environment interaction studies underscore the value of integrating SDH with multi-omics in prospective birth cohort studies, especially among high-risk Black women. In an era of rapid advancements in biomedical sciences and technologies and a growing number of prospective birth cohort studies, we have unprecedented opportunities to advance this field and finally address the long history of health disparities in PTB.

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“…Amongmost patients, no test absolutely will determine the correct diagnosis. Cases sometimes require several tests that need an extended period, moreover the worry of meeting a practitioner 14 .…”

Section: Introductionmentioning

confidence: 99%

“…Epigenetics possesses the possibility of being utilized as a biomarker of illness identification and treatment, illness observation, as well as therapy reaction. Over the last years, pharmacogenetics has gained vast attention also epigenetic drug (epidrug) improvement has made considerable progress 14 .…”

Section: Introductionmentioning

confidence: 99%

Epigenetics and familial mediterranean fever

Lotfy

Ali

Zarouk

et al. 2021

Azhar International Journal of Pharmaceutical and Medical Scien

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Throughout the last 20 years, the concept of auto-inflammation is developed, culminating with the finding of how gene mutations of Mediterranean Fever (MEFV) seemed to be causally linked to Familial Mediterranean fever (FMF). The autoinflammatory illnesses presently constitute a wide variety of disorders that have mutual signs of frequent fever, the incidence of hyper-reactive immune cells of hereditary origin, and indicators of inflammation that may occur systemically or specific to an organ with no autoimmunity specific infection. The key causes of the unregulated inflammation are the myeloid innate immune cells which mainly induced production of excessive inflammatory cytokines as IL-1β and IL-18. Deficiencies through various signalling mechanisms regulating innate immune response, especially a single and even multiple inflammasomes hyperreactivity, remain the essence of pathological autoinflammatory phenotype. While FMF would be a monogenic autoinflammatory syndrome, it is genetically complicated and affected by environmental influences. Lately, epigenetic dysregulation has appeared to be a further cause of pathogenesis.Throughout this survey, we are addressing the epigenetic involvement pathways within (FMF).

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Epigenetics in Health and Disease

Cited by 414 publications

References 197 publications

DNA methylation as predictive marker of response to immunotherapy?

DNA methylation as predictive marker of response to immunotherapy?

Gaining a deeper understanding of social determinants of preterm birth by integrating multi-omics data

Epigenetics and familial mediterranean fever

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