Epigenetics in Liver Disease

Stellate Cells and Hepatic Fibrosis

“…The distinctions between transcriptional and epigenetic control of important proactivation pathways, exemplified by GIV and STAT3, is an emerging field that has been reviewed recently [126][127][128]. Recent advances include the identification of several transcriptional control programs mediated by absent, small, or homeotic disc 1 (ASH1) [129] and myocardin-related transcription factor A (MRTF-A) [130].…”

Epigenetic modifications as regulatory elements of autophagy in cancer

“…Each histone protein can be regulated by post-translational modifications in various ways including acetylation, methylation, ubiquitination and so on [29]. Histone acetylation, the best-studied modifications, is mediated by acetyltransferases (HATs) and histone deacetylases (HDACs).…”

Looking Beyond Sorafenib to Treat Advanced Hepatocellular Carcinoma

“…Epigenetic modifications including histone deacetylation in the tumor cells have been implicated in developing resistance to anti-cancer drugs as well as poorer histology and differentiation of HCC leading to more advanced tumors and poor prognosis. 11,12 Hence, a combination of a kinase inhibitor with an epigenetic regulator is a theoretically attractive strategy to break this resistance. However, there is always the fear of drug interactions and incremental toxicity with such combinations.…”