Epigenetics in Periodontal Diseases

Akhilan,; Chaurasia,

doi:10.21767/2472-1158.100064

Cited by 1 publication

(2 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Histone modifications include the process of acetylation or deacetylation through enzymatic action, which results in chromatin remodeling that then influences gene expression [ 34 , 39 ]. The genetic material within humans is structured as a DNA helix packed up in the cell nucleus in the form of chromatin [ 31 ].…”

Section: Epigeneticsmentioning

confidence: 99%

“…Periodontitis and periodontal disease construe significant destruction of the tooth-supporting structures and loss of bone with eventual loss of teeth themselves. Epigenetic mechanisms in turn regulate the effect of cytokines, such as interleukin-1 (IL-1) and IL-6, which are responsible for the progression of periodontitis [ 39 ]. In their study, Oliveira et al [ 45 ] reported significant methylation patterns of the IL-8 gene promoter region in smokers with chronic periodontitis compared with healthy non-smoker counterparts.…”

Section: Epigenetics and Periodontal Diseasementioning

confidence: 99%

See 1 more Smart Citation

Emerging Role of Epigenetics in Explaining Relationship of Periodontitis and Cardiovascular Diseases

et al. 2021

View full text Add to dashboard Cite

Cardiovascular diseases such as ischemic heart diseases or stroke are among the leading cause of deaths globally, and evidence suggests that these diseases are modulated by a multifactorial and complex interplay of genetic, environmental, and lifestyle factors. Genetic predisposition and chronic exposure to modifiable risk factors have been explored to be involved in the pathophysiology of CVD. Environmental factors contribute to an individual’s propensity to develop major cardiovascular risk factors through epigenetic modifications of DNA and histones via miRNA regulation of protein translation that are types of epigenetic mechanisms and participate in disease development. Periodontal disease (PD) is one of the most common oral diseases in humans that is characterized by low-grade inflammation and has been shown to increase the risk of CVDs. Risk factors involved in PD and CVD are determined both genetically and behaviorally. Periodontal diseases such as chronic inflammation promote DNA methylation. Epigenetic modifications involved in the initiation and progression of atherosclerosis play an essential role in plaque development and vulnerability. Epigenetics has opened a new world to understand and manage human diseases, including CVDs and periodontal diseases. Genetic medicine has started a new era of epigenetics to overcome human diseases with various new methodology. Epigenetic profiling may aid in better diagnosis and stratification of patients showing potential predisposed states for disease. A better understanding of the exact regulatory mechanisms of epigenetic pathways driving inflammation is slowly emerging and will aid in developing novel tools for the treatment of disease.

show abstract

Section: Epigeneticsmentioning

confidence: 99%

Section: Epigenetics and Periodontal Diseasementioning

confidence: 99%