Epigenetics of obesity

Драпкина, О. М.; Kim, O. T.

doi:10.15829/1728-8800-2020-2632

Cited by 9 publications

(2 citation statements)

References 81 publications

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“…During these phases, elements such as maternal nutrition, stress, and pollutant exposure can significantly sway the risk of obesity and associated ailments. [84]. Environmental aspects, including dietary influences, can epigenetic events and the expression of genes pivotal to weight regulation and the onset of obesity.…”

Section: Epigenetic Influences On Obesitymentioning

confidence: 99%

Obesity and Diabetes Mellitus 2: Interrelated Relative Relationship

Albajy,

Mihailescu

2023

Int J Res Rev

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Obesity, defined as the excessive accumulation of body fat, is determined using body mass index (BMI) classifications. This condition is a primary contributor to several severe health issues, encompassing heart diseases, diabetes, hypertension, and specific cancers. Predominantly, environmental influences and lifestyle choices, such as inactive behaviors and unhealthy diets, are the culprits behind obesity. Common therapeutic interventions for obesity include dietary modifications, physical activity, and in some cases, medications or surgical procedures. A heightened BMI can signal the potential onset of Type 2 diabetes, given that an increased fat percentage elevates the risk of this disease. Globally, obesity rates have surged, positioning it as a top health concern and a notable medical condition. This rise is largely attributed to the widespread adoption of poor dietary practices and inactive lifestyles. Consequently, there's a parallel increase in Type 2 diabetes cases, especially among those labeled as "extremely obese." The relationship between obesity and Type 2 diabetes is intricate, stemming from complex cellular and physiological interactions. These interactions influence beta cell functions, modify the biology of fat tissues, and amplify insulin resistance. Given the multifaceted link between obesity and Type 2 diabetes, it's imperative to consider this when formulating efficient prevention and treatment methodologies. Notably, due to shifts in the functionality of pancreatic beta cells, the nature of adipose tissue, and insulin resistance, adults with significant weight gains are predisposed to Type 2 diabetes. Addressing this escalating health challenge necessitates strategies focusing on both weight management and metabolic health optimization. Keywords: Obesity, Type 2 Diabetes, Insulin resistance, Adipose tissue, Free fatty acid

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Section: Epigenetic Influences On Obesitymentioning

confidence: 99%

Obesity and Diabetes Mellitus 2: Interrelated Relative Relationship

Albajy,

Mihailescu

2023

Int J Res Rev

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“…Obesity is a multifactorial disease characterized by increased fat deposition [8]. Few cases of obesity are due to monogenic causes, and there is an increasing number of cases of obesity due to environmental factors and individual genetic predisposition [9]. Changes in the gut microbiome, infectious processes, medication side effects, sleep disturbances, maternal age at birth, duration of breastfeeding, negative environmental factors, and epigenetic changes contribute to the development of obesity [10,11].…”

Section: Introductionmentioning

confidence: 99%

Anti-Obesity Effects of Chitosan and Its Derivatives

Shagdarova,

Konovalova,

Varlamov

et al. 2023

Polymers

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The number of obese people in the world is rising, leading to an increase in the prevalence of type 2 diabetes and other metabolic disorders. The search for medications including natural compounds for the prevention of obesity is an urgent task. Chitosan polysaccharide obtained through the deacetylation of chitin, and its derivatives, including short-chain oligosaccharides (COS), have hypolipidemic, anti-inflammatory, anti-diabetic, and antioxidant properties. Chemical modifications of chitosan can produce derivatives with increased solubility under neutral conditions, making them potential therapeutic substances for use in the treatment of metabolic disorders. Multiple studies both in animals and clinical trials have demonstrated that chitosan improves the gut microbiota, restores intestinal barrier dysfunction, and regulates thermogenesis and lipid metabolism. However, the effect of chitosan is rather mild, especially if used for a short periods, and is mostly independent of chitosan’s physical characteristics. We hypothesized that the major mechanism of chitosan’s anti-obesity effect is its flocculant properties, enabling it to collect the chyme in the gastrointestinal tract and facilitating the removal of extra food. This review summarizes the results of the use of COS, chitosan, and its derivatives in obesity control in terms of pathways of action and structural activity.

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Factors associated with iron deficiency in heart failure

Смирнова

Чижов

2023

Cardiovasc Ther Prev

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Aim. To establish the factors associated with iron deficiency (ID) in pa- tients with heart failure (HF).Material and methods. We examined 294 patients with NYHA class II-IV HF as follows: 213 — with ID, 81 — without ID. All patients underwent a clinical examination, collection of medical history taking into account the presence, duration and severity of comorbidities, drug history, echocardiography, complete blood count, serum iron, ferritin, transferrin, transferrin saturation, soluble transferrin receptors, hepcidin, erythropoietin, and routine laboratory tests. In addition, we determined the presence and severity of asthenia, anxiety, and depression.Results. Twenty-nine clinical, laboratory and echocardiographic parameters were established, which had significant differences in patients with and without ID and significant correlations with ID. Determining the odds ratio for these 29 parameters revealed 7 factors significantly associated with ID in patients with HF. Using multivariate logistic regression, a significant cumulative effect of these factors on the ID risk was established.Conclusion. ID in patients with HF is associated with age, class II-IV HF, elevated hepcidin levels, duration of hypertension and diabetes, history of using angiotensin-converting enzyme inhibitors and novel oral anticoagulants for >1 year.

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Epigenetics of obesity

Cited by 9 publications

References 81 publications

Obesity and Diabetes Mellitus 2: Interrelated Relative Relationship

Obesity and Diabetes Mellitus 2: Interrelated Relative Relationship

Anti-Obesity Effects of Chitosan and Its Derivatives

Factors associated with iron deficiency in heart failure

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