Epigenetics of oral infection and inflammatory diseases—DNA methylation changes in infections and inflammation diseases

Abiko, Yoshihiro; Uehara, Osamu; Fukumoto, Satoshi; Ohta, Tohru

doi:10.1016/j.job.2014.06.004

Cited by 6 publications

(6 citation statements)

References 61 publications

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“…Many environmental factors such as tobacco smoke, alcohol, microbes and infectious agents affect periodontal tissues. Many genes may be modified through hypermethylation (1)(2)(3)(4)(5)(6).…”

Section: Resultsmentioning

confidence: 99%

“…As DNA hypermethylation often induces downregulated expression of homeostatic genes such as tumor suppressor genes, it is most extensively studied in cancer . It has recently been shown that DNA hypermethylation may cause other common diseases such as diabetes, metabolic diseases, allergies, autoimmune diseases and neurodegenerative diseases . DNA hypermethylation has also recently been implicated in human periodontal disease .…”

mentioning

confidence: 99%

“…Periodontal pathogens are crucial environmental factors in the development of periodontal disease. Periodontal pathogens and their lipopolysaccharides (LPS) can cause hypermethylation in certain genes . LPS is used as a bacterial toxin to elicit acute responses in experimental models of infection .…”

mentioning

confidence: 99%

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DNA hypermethylation of extracellular matrix‐related genes in human periodontal fibroblasts induced by stimulation for a prolonged period with lipopolysaccharide derived from Porphyromonas gingivalis

Takai

Uehara

Harada

et al. 2015

J of Periodontal Research

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Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

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DNA hypermethylation of extracellular matrix‐related genes in human periodontal fibroblasts induced by stimulation for a prolonged period with lipopolysaccharide derived from Porphyromonas gingivalis

Takai

Uehara

Harada

et al. 2015

J of Periodontal Research

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“…These studies have concentrated on alterations in the methylation profile as the major epigenetic change. Abiko and colleagues summarized recent publications on methylation in oral inflammatory diseases, in order to discuss methylation as a cause of disease and make recommendations about therapeutic targets [110]. DNA methylation in oral cancer is well documented.…”

Section: Involvement Of Epigenetics In Development Of Diseasesinvolvementioning

confidence: 99%

Oral Biosciences: The annual review 2014

Ohshima

2015

Journal of Oral Biosciences

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“…The extent of DNA methylation influences gene transcription and chromatin structure, and can change during bacterial infection [ 10 , 11 ]. DNA methyltransferase (Dnmt)3b is one of the main enzymes mediating de novo DNA methylation [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Bronchial epithelial DNA methyltransferase 3b dampens pulmonary immune responses during Pseudomonas aeruginosa infection

et al. 2021

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DNA methyltransferase (Dnmt)3b mediates de novo DNA methylation and modulation of Dnmt3b in respiratory epithelial cells has been shown to affect the expression of multiple genes. Respiratory epithelial cells provide a first line of defense against pulmonary pathogens and play a crucial role in the immune response during pneumonia caused by Pseudomonas (P.) aeruginosa, a gram-negative bacterium that expresses flagellin as an important virulence factor. We here sought to determine the role of Dntm3b in respiratory epithelial cells in immune responses elicited by P. aeruginosa. DNMT3B expression was reduced in human bronchial epithelial (BEAS-2B) cells as well as in primary human and mouse bronchial epithelial cells grown in air liquid interface upon exposure to P. aeruginosa (PAK). Dnmt3b deficient human bronchial epithelial (BEAS-2B) cells produced more CXCL1, CXCL8 and CCL20 than control cells when stimulated with PAK, flagellin-deficient PAK (PAKflic) or flagellin. Dnmt3b deficiency reduced DNA methylation at exon 1 of CXCL1 and enhanced NF-ĸB p65 binding to the CXCL1 promoter. Mice with bronchial epithelial Dntm3b deficiency showed increased Cxcl1 mRNA expression in bronchial epithelium and CXCL1 protein release in the airways during pneumonia caused by PAK, which was associated with enhanced neutrophil recruitment and accelerated bacterial clearance; bronchial epithelial Dnmt3b deficiency did not modify responses during pneumonia caused by PAKflic or Klebsiella pneumoniae (an un-flagellated gram-negative bacterium). Dnmt3b deficiency in type II alveolar epithelial cells did not affect mouse pulmonary defense against PAK infection. These results suggest that bronchial epithelial Dnmt3b impairs host defense during Pseudomonas induced pneumonia, at least in part, by dampening mucosal responses to flagellin.

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Epigenetics of oral infection and inflammatory diseases—DNA methylation changes in infections and inflammation diseases

Cited by 6 publications

References 61 publications

DNA hypermethylation of extracellular matrix‐related genes in human periodontal fibroblasts induced by stimulation for a prolonged period with lipopolysaccharide derived from Porphyromonas gingivalis

DNA hypermethylation of extracellular matrix‐related genes in human periodontal fibroblasts induced by stimulation for a prolonged period with lipopolysaccharide derived from Porphyromonas gingivalis

Oral Biosciences: The annual review 2014

Bronchial epithelial DNA methyltransferase 3b dampens pulmonary immune responses during Pseudomonas aeruginosa infection

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