Epigenetics/Programming in the<scp>HPA</scp>Axis

Buschdorf, Jan Paul; Meaney, Michael J.

doi:10.1002/cphy.c140027

Cited by 58 publications

(50 citation statements)

References 237 publications

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“…2013, Kundakovic & Champagne 2014, Betancourt et al . 2015, Buschdorf & Meaney 2015, Cunliffe 2015, Demetriou et al . 2015, Provencal & Binder 2015, Stringhini et al .…”

Section: Resultsmentioning

confidence: 99%

“…2007, Weeratunga et al . 2014, Buschdorf & Meaney 2015). Eriksson and Forsen (2002) describe the association between low birth weight and an increased risk for adult cardiovascular disease due to adaptation to metabolic demands in utero.…”

Section: Resultsmentioning

confidence: 99%

“…The third defining attributechanges in an individual's biology are stable and long termhas been demonstrated through research in the emerging field of epigenetics. This field of work has demonstrated that persistent and sometimes heritable, alterations in the human genome may be caused by changes in DNA methylation and chromatin structure among cells such as neurons and immune cells, which remain stable over time (Sasaki et al 2013, Buschdorf & Meaney 2015. Adults with traumatic childhood experiences, including physical abuse and neglect, demonstrated altered patterns of DNA methylation in the hippocampus, compared with controls (Sasaki et al 2013).…”

Section: Concept Evaluationmentioning

confidence: 99%

“…Many authors define biological programming as the establishment of the functioning parameters (i.e. the set-points) for biological systems resulting from early life experiences (Peck 1994, Macintyre 1997, Wadsworth 1997a,b, Blane et al 2007, Weeratunga et al 2014, Buschdorf & Meaney 2015. Eriksson and Forsen (2002) describe the association between low birth weight and an increased risk for adult cardiovascular disease due to adaptation to metabolic demands in utero.…”

Section: Concept Analysismentioning

confidence: 99%

“…As previously described, experience-dependent cases of biological programming do not require a sensitive period to affect biological systems (Rutter 2009). Conversely, almost all cases of biological embedding in the literature point to a sensitive period in developmentone where the organism is particularly vulnerable to environmental influencesduring which experiences exert changes in biological processes (Hertzman 1999, Shonkoff et al 2009, Hertzman & Boyce 2010, Danese et al 2011, Miller et al 2011, Danese & McEwen 2012, Masten & Narayan 2012, McEwen 2012, Carroll et al 2013, Clayton 2013, Kelly-Irving et al 2013, Sasaki et al 2013, Bateson et al 2015, Boyce & Kobor 2015, Buschdorf & Meaney 2015, Cunliffe 2015, Demetriou et al 2015, Provencal & Binder 2015, Thomason et al 2015. During the sensitive or critical periodcommonly defined as early childhoodthe brain and body are undergoing rapid growth and maturation, allowing for significant plasticity (Sasaki et al 2013, Boyce & Kobor 2015, Provencal & Binder 2015, Thomason et al 2015.…”

Section: Suggestions For Further Concept Delineationmentioning

confidence: 99%

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Biological embedding: evaluation and analysis of an emerging concept for nursing scholarship

Nist

2016

Journal of Advanced Nursing

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Aim The purpose of this paper is to report the analysis of the concept of biological embedding. Background Research that incorporates a life course perspective is becoming increasingly prominent in the health sciences. Biological embedding is a central concept in life course theory and may be important for nursing theories to enhance our understanding of health states in individuals and populations. Before the concept of biological embedding can be used in nursing theory and research, an analysis of the concept is required to advance it toward full maturity. Design Concept analysis. Data Sources PubMed, CINAHL and PsycINFO were searched for publications using the term ‘biological embedding’ or ‘biological programming’ and published through 2015. Methods An evaluation of the concept was first conducted to determine the concept’s level of maturity and was followed by a concept comparison, using the methods for concept evaluation and comparison described by Morse. Results A consistent definition of biological embedding – the process by which early life experience alters biological processes to affect adult health outcomes – was found throughout the literature. The concept has been used in several theories that describe the mechanisms through which biological embedding might occur and highlight its role in the development of health trajectories. Biological embedding is a partially mature concept, requiring concept comparison with an overlapping concept – biological programming – to more clearly establish the boundaries of biological embedding. Conclusions Biological embedding has significant potential for theory development and application in multiple academic disciplines, including nursing.

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“…2013, Kundakovic & Champagne 2014, Betancourt et al . 2015, Buschdorf & Meaney 2015, Cunliffe 2015, Demetriou et al . 2015, Provencal & Binder 2015, Stringhini et al .…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Concept Evaluationmentioning

confidence: 99%

Section: Concept Analysismentioning

confidence: 99%

Section: Suggestions For Further Concept Delineationmentioning

confidence: 99%

See 3 more Smart Citations

Biological embedding: evaluation and analysis of an emerging concept for nursing scholarship

Nist

2016

Journal of Advanced Nursing

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Effects of social environments on male primate HPG and HPA axis developmental programming

Brown,

Gettler,

Rosenbaum

2024

Developmental Psychobiology

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Developmental plasticity is particularly important for humans and other primates because of our extended period of growth and maturation, during which our phenotypes adaptively respond to environmental cues. The hypothalamus–pituitary–gonadal (HPG) and hypothalamus–pituitary–adrenal (HPA) axes are likely to be principal targets of developmental “programming” given their roles in coordinating fitness‐relevant aspects of the phenotype, including sexual development, adult reproductive and social strategies, and internal responses to the external environment. In social animals, including humans, the social environment is believed to be an important source of cues to which these axes may adaptively respond. The effects of early social environments on the HPA axis have been widely studied in humans, and to some extent, in other primates, but there are still major gaps in knowledge specifically relating to males. There has also been relatively little research examining the role that social environments play in developmental programming of the HPG axis or the HPA/HPG interface, and what does exist disproportionately focuses on females. These topics are likely understudied in males in part due to the difficulty of identifying developmental milestones in males relative to females and the general quiescence of the HPG axis prior to maturation. However, there are clear indicators that early life social environments matter for both sexes. In this review, we examine what is known about the impact of social environments on HPG and HPA axis programming during male development in humans and nonhuman primates, including the role that epigenetic mechanisms may play in this programming. We conclude by highlighting important next steps in this research area.

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The biological embedding of neonatal stress exposure: A conceptual model describing the mechanisms of stress‐induced neurodevelopmental impairment in preterm infants

Nist

Harrison

Steward

2018

Research in Nursing & Health

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The biological embedding of early life stress exposure may result in life‐long neurodevelopmental impairment in preterm infants. Infants hospitalized in the neonatal intensive care unit are exposed to significant experiential, environmental, and physiologic stressors over the course of their extended hospitalization. Stress exposure during the sensitive period of brain development may alter biological processes, including functioning of the immune system, the autonomic nervous system, and the hypothalamic‐pituitary‐adrenal axis as well as gene expression. These alterations may subsequently affect brain structure and function. Changes to these processes may mediate the relationship between neonatal stress exposure and neurodevelopment in preterm infants and represent potential therapeutic targets to improve long‐term outcomes. The purpose of this paper is to introduce a conceptual model, based on published research, that describes the mechanisms mediating stress exposure and neurodevelopment impairment in preterm infants and to provide the theoretical foundation on which to base future descriptive research, intervention studies, and clinical care.

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Epigenetics/Programming in theHPAAxis

Cited by 58 publications

References 237 publications

Biological embedding: evaluation and analysis of an emerging concept for nursing scholarship

Biological embedding: evaluation and analysis of an emerging concept for nursing scholarship

Effects of social environments on male primate HPG and HPA axis developmental programming

The biological embedding of neonatal stress exposure: A conceptual model describing the mechanisms of stress‐induced neurodevelopmental impairment in preterm infants

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