Epigenetics rules

Popova, Evgenya Y.; Barnstable, Colin J.

doi:10.1007/s12177-012-9088-8

Cited by 2 publications

(2 citation statements)

References 5 publications

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“…Conrad H. Waddington used it to explain why embryonic stem cells differentiate into many different tissues despite having the same genetic material. Thus, this science covers problems of variation in gene expression, but does not include changes associated with the modification of nucleotide sequences in DNA [ 83 ]. Factors that influence gene expression variability are environmental factors, also known as external factors.…”

Section: Nutritional Programmingmentioning

confidence: 99%

Nutritional Programming: History, Hypotheses, and the Role of Prenatal Factors in the Prevention of Metabolic Diseases—A Narrative Review

et al. 2022

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Childhood obesity and the numerous lifestyle diseases associated with it are undoubtedly among the key problems in modern medicine and public health. However, this problem concerns not only the present or immediate future, but also the longer term. Adult health is fundamentally shaped in the first years of life and in the fetal period. The preconceptual period, which is responsible for the proper preparation of the internal environment for the life and development of the fetus during pregnancy, is also significant. A special role in describing the phenomenon of conditioning the metabolism of the new human being is now attributed to the theory of nutritional programming. Research in this area was pioneered by David Barker, who put forward the theory of the “stunted phenotype” and described the relationship between a child’s birth weight, which is largely a consequence of the mother’s feeding behaviour, and diseases such as ischaemic heart disease, type 2 diabetes (T2D), dyslipidemia, or high blood pressure. This narrative review aims to provide an overview of the history, theory, and prenatal mechanisms involved in nutritional programming and its relationship to childhood obesity and other metabolic diseases.

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Section: Nutritional Programmingmentioning

confidence: 99%

Nutritional Programming: History, Hypotheses, and the Role of Prenatal Factors in the Prevention of Metabolic Diseases—A Narrative Review

et al. 2022

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“…Recent years and advances in molecular biology have made it possible to distinguish epigenetics as a separate field of science. Conventionally, epigenetics is concerned with the study of changes in gene expression caused by mechanisms other than changes in the nucleotide sequence of DNA [113,114].…”

Section: Overview Of Epigeneticsmentioning

confidence: 99%

Epigenetic Issues. The Link Between Microbiota and Gestational Diabetes.

Mora-Janiszewska¹,

Faryniak-Zuzak²,

Darmochwał-Kolarz³

2022

Preprint

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Gestational diabetes (GDM) is considered a significant and increasing problem worldwide. The growing body of evidence points out that a hostile intrauterine environment in mothers with GDM via epigenetic mechanisms induces "diabetogenic" and "obesogenic" changes in an offspring's DNA. This sets in motion a vicious intergenerational cycle of metabolic diseases gradually deteriorating the health of the human population. One of the most important players in this process seems to be altered microbiota/microbiome. There is a chance that the identification of specific epigenetic marks may provide a key for future diagnostic, prognostic and therapeutic solutions/measures in the field of person-alized medicine. Given the reversibility of most epigenetic changes, an opportunity arises to improve the long-term health of the human population/race. In this manuscript, we aim to summarize available data on epigenetic changes among women suffering from GDM and their progeny in association with changes in microbiome.

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Epigenetics rules

Cited by 2 publications

References 5 publications

Nutritional Programming: History, Hypotheses, and the Role of Prenatal Factors in the Prevention of Metabolic Diseases—A Narrative Review

Nutritional Programming: History, Hypotheses, and the Role of Prenatal Factors in the Prevention of Metabolic Diseases—A Narrative Review

Epigenetic Issues. The Link Between Microbiota and Gestational Diabetes.

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