Epigenome-Wide Associations of Placental DNA Methylation and Behavioral and Emotional Difficulties in Children at 3 Years of Age

Nakamura, Aurélie; Broséus, Lucile; Tost, Jörg; Vaiman, Daniel; Martins, Sílvia S.; Keyes, Katherine M.; Bonello, Kim; Fekom, Mathilde; Strandberg‐Larsen, Katrine; Sutter-Dallay, Anne-Laure; Heude, Barbara; Melchior, Maria; Lepeule, Johanna

doi:10.3390/ijms241411772

Cited by 3 publications

(1 citation statement)

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“…Nakamura (Nakamura et al, 2023) states that the placenta epigenome can be considered a biochemical record of the prenatal environment and a potential mechanism of its association with future fetal health. His study provides the first evidence of associations between placental DNA methylation and the baby's behavioral and emotional difficulties.…”

Section: Introductionmentioning

confidence: 99%

What Are We Like, Is It a Matter of Genetic Inheritance or Not?

mariano

2023

Preprint

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Background Scientific literature in psychology considers personality as an organization of ways of being, knowing, and acting that ensures unity, coherence and continuity, stability and planning of the individual's relations with the world (Caprara & Gennaro, 1994). Personality is the outcome of two distinct constructs: Temperament and Character. So, personality is the result of the interaction between biological aspects (temperament) and the experiences that anybody experiences in his own life, interacting with the environment (Cloninger et al., 1993). Scientific literature now largely agrees that adversity in the early years of life has broad long-term consequences on the neuroendocrine, immune, and metabolic systems (Kim et al., 2019), as well as on neuroplasticity and neuronal morphology that alter the overall evolution of (van Bodegom, et al., 2017; Edwards et al., 2010). Here we analyze the hypothesis that maternal environmental factors (air and chemical pollutants, maternal health, eating behaviors, maternal and fetal stresses, caregivers' behaviors, etc.) can cause epigenetic alterations in the offspring in the prenatal and perinatal period that shape the trait's personality of the offspring themselves and that orient part of their character in adult life. Methods The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement was used to develop this systematic review. PubMed, Scopus, PsycINFO, and Biosis databases were searched for primary research articles published between 2010 and 2023 looking for English language articles containing the term "prenatal" and any of the following terms: "anxiety"; "brain development"; "depression"; "gestation"; "maternal health"; "maternal stress"; "mental health"; "newborn health"; "perinatal programming"; "pregnancy"; "prenatal stress"; "resilience to stress"; "transgenerational epigenetic inheritance"; "personality"; "personality trait"; "environmental epigenetics". Retrieved articles were screened and a subset of relevant abstracts was then selected for a more detailed evaluation. The final studies selected consisted of those resources that directly evaluated the relationship between maternal environmental factors and the personality traits of the offspring. Results and Conclusions One hundred and eleven studies were identified but only three met the primary question. There is evidence to support the hypothesis of correlations between environmental exposure during the intrauterine fetal period and personality traits of the newborn. Limits: multiple limitations were found based on the lack of research on this specific topic, although such a field of research can be important for developing effective strategies for primary prevention.

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Section: Introductionmentioning

confidence: 99%

What Are We Like, Is It a Matter of Genetic Inheritance or Not?

mariano

2023

Preprint

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Prenatal bisphenol analogs exposure and placental DNA hypomethylation of genes in the PPAR signaling pathway: Insights for bisphenol analogs’ effects on infant anthropometry

Ji,

Zhu,

Wang

et al. 2025

Environmental Research

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What Are We Like: Is It a Matter of Genetic Inheritance or Not? A Systematic Review

Mariano

2024

Preprint

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BACKGROUND. Scientific literature in psychology considers personality as an organization of ways of being, knowing, and acting that ensures unity, coherence, and continuity, stability, and planning of the individual's relations with the world. Personality is the outcome of two distinct constructs: Temperament and Character. So, personality is the result of the interaction between biological aspects (Temperament) and experiences of everyone in life, interacting with the environment[1]. Scientific literature now largely agrees that adversity in the early years of life has broad long-term consequences on the neuroendocrine, immune, and metabolic systems[2] as well as on neuroplasticity and neuronal morphology. Here we analyze the hypothesis that maternal environmental factors (air and chemical pollutants, maternal health, eating behaviors, maternal and fetal stresses, caregivers' behaviors, etc.) can cause epigenetic alterations in the offspring during the prenatal that shape the trait's personality of the offspring themselves and that partially influence their. METHODS. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement was used to develop this systematic review. PubMed, Scopus, PsycINFO, and Biosis databases were searched for primary research articles published between 2010 and 2023 looking for English language articles containing the term "prenatal" and any of the following terms: "anxiety", "brain development", "depression", "gestation", "maternal health", "maternal stress", "mental health", "newborn health", "perinatal programming", "pregnancy", "prenatal stress", "resilience to stress", "transgenerational epigenetic inheritance", "personality", "personality trait", "environmental epigenetics". Relevant papers evaluating the relationship between maternal environmental factors and the personality traits of the offspring were subjected to a more thorough evaluation. RESULTS, AND CONCLUSIONS. Among the 111 studies identified, only 3 met the primary question. There is evidence to support the hypothesis of correlations between environmental exposure during the intrauterine fetal period and personality traits of the newborn. Limits: Multiple limitations were found based on the lack of research on this specific topic, although such a field of research can be important for developing effective strategies for primary prevention.

show abstract

Epigenome-Wide Associations of Placental DNA Methylation and Behavioral and Emotional Difficulties in Children at 3 Years of Age

Cited by 3 publications

References 102 publications

What Are We Like, Is It a Matter of Genetic Inheritance or Not?

What Are We Like, Is It a Matter of Genetic Inheritance or Not?

Prenatal bisphenol analogs exposure and placental DNA hypomethylation of genes in the PPAR signaling pathway: Insights for bisphenol analogs’ effects on infant anthropometry

What Are We Like: Is It a Matter of Genetic Inheritance or Not? A Systematic Review

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