Epigenomics: Genome-Wide Study of Methylation Phenomena

Novik, Karen; Nimmrich, Inko; Genc, B; Maier, Sabine; Piepenbrock, Christian; Olek, Alexander; Beck, Stephan

doi:10.21775/cimb.004.111

Cited by 42 publications

(2 citation statements)

References 168 publications

(170 reference statements)

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“…This approach is invaluable in observing the differential expression of genes providing important insights for further research [5 and 6]. Epigenetics are the heritable changes that occur beyond alterations in the DNA sequences, which include DNA methylation and post translational modification of chromosomal proteins [7,8]. The combination of epigenetics and genomics has given rise to novel omics technique known as epigenomics, which aims to unravel the genetic regulation and its role in plant breeding unlike genomics, epigenomics is also influenced by biotic and abiotic stress.…”

Section: Introductionmentioning

confidence: 99%

Metabolomics and Metabolic Engineering for Crop Improvement: Current Trends and Future Prospects

Singh,

Karadagi,

Doggalli

et al. 2024

PCBMB

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Metabolomics is a rising field within the realm of “omics,” focusing on the detection and measurement of metabolites and chemical markers associated with cellular regulatory mechanisms across various biological organisms. The exploration of metabolomic control in plant life plays a imperative role in comprehending their ability to adapt, acclimate, and defend against environmental pressures by generating a diverse array of metabolites. Furthermore, the application of metabolomics holds promise in the characterization of plant traits, offering significant prospective for amalgamation into genome editing initiatives aimed at advancing the development of enhanced, future-generation crops. The forefront technologies have introduced economical and high-capacity methods to molecularly analyze the operation of cells or organisms. Cutting-edge analytical methods in metabolomics, such as nuclear magnetic resonance spectroscopy (NMR), liquid chromatography mass-spectrometry (LC-MS), gas chromatography-mass (GC-MS) and high performance liquid chromatography (HPLC) have accelerated metabolic profiling. This review provides an insights into the latest tools in plant metabolomics for enhancing crops and process of plant metabolome research, engaging in plant mechanisms especially for tolerating biotic and abiotic stresses. This review also provide potential approaches to metabolomics through metabolic engineering such as miRNA- and RNAi-Mediated Metabolic Engineering, Genome editing mediated metabolic Engineering etc

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Section: Introductionmentioning

confidence: 99%

Metabolomics and Metabolic Engineering for Crop Improvement: Current Trends and Future Prospects

Singh,

Karadagi,

Doggalli

et al. 2024

PCBMB

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“…Increasing evidence suggests that one mechanism for gene by environment interactions that differentiates risk versus resilience involves epigenetic processes (Yehuda & Bierer, 2009 ; Yehuda & LeDoux, 2007 ). The most studied epigenetic mark in the field of mental health is DNA methylation (DNAm), a chemical modification of DNA at cytosine-guanine dinucleotides (CpGs) which can alter gene regulation (Novik et al, 2002 ). It has been suggested that the epigenome can accommodate environmental influences in the form of long-lasting DNAm modifications which alter the central nervous system’s structures and functioning (Aristizabal et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

No association between war-related trauma or PTSD symptom severity and epigenome-wide DNA methylation in Burundian refugees

Mattonet

Scharpf

Block

et al. 2023

European Journal of Psychotraumatology

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Background: War-related trauma is associated with varying posttraumatic stress disorder (PTSD) prevalence rates in refugees. In PTSD development, differential DNA methylation (DNAm) levels associated with trauma exposure might be involved in risk versus resilience processes. Studies investigating DNAm profiles related to trauma exposure and PTSD among refugees remain sparse. Objective: The present epigenome-wide association study investigated associations between war-related trauma, PTSD, and altered DNAm patterns in Burundian refugee families with 110 children and their 207 female and male caregivers. Method: War-related trauma load and PTSD symptom severity were assessed in structured clinical interviews with standardised instruments. Epigenome-wide DNAm levels were quantified from buccal epithelia using the Illumina EPIC beadchip. Results: Controlling for biological confounders, no significant epigenome-wide DNAm alterations associated with trauma exposure or PTSD were identified in children or caregivers ( FDRs > .05). Co-methylated positions derived as modules from weighted gene correlation network analyses were not significantly associated with either war-related trauma experience in children or caregivers or with PTSD. Conclusions: These results do not provide evidence for altered DNAm patterns associated with exposure to war-related trauma or PTSD.

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Intergenerational transmission of trauma effects: putative role of epigenetic mechanisms

2018

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This paper reviews the research evidence concerning the intergenerational transmission of trauma effects and the possible role of epigenetic mechanisms in this transmission. Two broad categories of epigenetically mediated effects are highlighted. The first involves developmentally programmed effects. These can result from the influence of the offspring's early environmental exposures, including postnatal maternal care as well as in utero exposure reflecting maternal stress during pregnancy. The second includes epigenetic changes associated with a preconception trauma in parents that may affect the germline, and impact fetoplacental interactions. Several factors, such as sex-specific epigenetic effects following trauma exposure and parental developmental stage at the time of exposure, explain different effects of maternal and paternal trauma. The most compelling work to date has been done in animal models, where the opportunity for controlled designs enables clear interpretations of transmissible effects. Given the paucity of human studies and the methodological challenges in conducting such studies, it is not possible to attribute intergenerational effects in humans to a single set of biological or other determinants at this time. Elucidating the role of epigenetic mechanisms in intergenerational effects through prospective, multi-generational studies may ultimately yield a cogent understanding of how individual, cultural and societal experiences permeate our biology.

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Epigenomics: Genome-Wide Study of Methylation Phenomena

Cited by 42 publications

References 168 publications

Metabolomics and Metabolic Engineering for Crop Improvement: Current Trends and Future Prospects

Metabolomics and Metabolic Engineering for Crop Improvement: Current Trends and Future Prospects

No association between war-related trauma or PTSD symptom severity and epigenome-wide DNA methylation in Burundian refugees

Intergenerational transmission of trauma effects: putative role of epigenetic mechanisms

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