Epikutantestung mit chemisch modifiziertem Kolophonium

Geier, J.; Hausen, B. M.

doi:10.1055/s-2006-925041

Cited by 5 publications

(9 citation statements)

References 3 publications

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“…It is reported that 45.5% colophonium-allergic patients were FM PT positive (20). A possible reason for this apparent cross-allergy is the same fragrant components being in both FM and colophonium (20). Our study also showed that the positive PT rate to colophonium in the patients with positive FM PT is higher than that in negative ones.…”

Section: Discussionsupporting

confidence: 64%

“…Colophonium has been used as an indicator for fragrance allergy. Previous studies found that FM and balsam of Peru PT-positive rates were high in colophonium-positive PT patients (20). It is reported that 45.5% colophonium-allergic patients were FM PT positive (20).…”

Section: Discussionmentioning

confidence: 93%

“…Previous studies found that FM and balsam of Peru PT-positive rates were high in colophonium-positive PT patients (20). It is reported that 45.5% colophonium-allergic patients were FM PT positive (20). A possible reason for this apparent cross-allergy is the same fragrant components being in both FM and colophonium (20).…”

Section: Discussionmentioning

confidence: 94%

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A clinical and patch test study of patients with positive patch test reactions to fragrance mix in China

Wang

et al. 2005

Contact Dermatitis

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The clinical and patch test (PT) features of patients with positive PT reactions to fragrance mix (FM) were studied. 378 consecutive eczema outpatients patch tested with a modified European standard series were analysed. 60 patients (15.9%) reacted to FM. No significant differences could be found between the ages of FM PT-positive and PT-negative patients [median age 40.5 (range from 18 years to 69 years) versus median age 37.5 (range from 5 years to 81 years), rank sum test, P = 0.301]. FM PT-positive rate in confirmed non-cosmetic allergic contact dermatitis patients was 30.4%, which was similar to that in confirmed cosmetic allergic contact dermatitis patients (30.4% versus 30%, chi(2) test, chi(2) = 0.0010, P = 0.972). The FM PT-positive rates were 10.8% in males and 18.2% in females (chi(2) test, chi(2) = 3.3443, P = 0.067). 76.7% of the patients with fragrance contact dermatitis were allergic to Chinese traditional medicine, which is much higher than that for cosmetic allergy (76.7% versus 43.3%, chi(2) test, chi(2) = 6.9446, P = 0.008). The positive PT rate to colophonium in the patients with positive PT reactions to FM is higher than that in the FM PT-negative patients (18.9% versus 3.0%, chi(2) test, chi(2) = 15.5471, P < 0.01). 62.5% of the patients reacted to colophonium were positive to FM. These results show that age has little effect on fragrance contact allergy. Other fragrant products besides cosmetics are also important sources of fragrance contact allergy. Chinese traditional medicine was an important factor in fragrance allergy in China. Patients with positive PT reactions to FM are more likely to react to colophonium.

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Section: Discussionsupporting

confidence: 64%

Section: Discussionmentioning

confidence: 93%

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A clinical and patch test study of patients with positive patch test reactions to fragrance mix in China

Wang

et al. 2005

Contact Dermatitis

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Section: Other Studies/contact Sensitisationmentioning

confidence: 99%

“…Dermal contact sensitisation is seen with different types of rosins and modified rosins and their components as well as with GEGR, GEWR, and GETOR (e.g. Downs and Sansom, 1999, Gaefvert et al, 1994, Hausen and Mohnert, 1989Shao et al, 1993;Geier and Hausen, 2006;Illing et al, 2009). Even though it was not possible to sensitise guinea pigs against purified abietic acid (Karlberg et al, 1985), Hausen and Mohnert (1989) found that of 44 dermatologic patients, 17 (39%) reacted positive to purified abietic acid as well as to standard rosin in a patch test.…”

Section: Other Studies/contact Sensitisationmentioning

confidence: 99%

Scientific Opinion on the safety of glycerol esters of gum rosin for the proposed uses as a food additive

2010

EFSA Journal

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The Panel on Food Additives and Nutrient Sources added to Food provides a scientific opinion evaluating the safety of glycerol esters of gum rosin (GEGR) for the proposed use as a stabilising and emulsifying food additive in certain beverages to a maximum level of 100 mg/l. The Joint FAO/WHO Expert Committee on Food Additives established a group ADI of 0-25 mg/kg bw/day for glycerol esters of wood rosin (GEWR) and GEGR and tentative specifications for GEGR pending the submission of additional data. GEGR are obtained by esterification of refined gum rosin and are described as a complex mixture of tri-and diglycerol esters of resin acids and a residual fraction of monoglycerol esters. Besides these esters, up to 4.2% free resin acids and up to 20.1% other non-acidic saponifiable and unsaponifiable substances are present in GEGR. The percentages of resin acids derived from the three fractions upon saponification of GEGR are known. However, data on the identity and quantity of individual components in the three fractions of GEGR are absent and also data on the proportions of glycerol monoesters, (1,2)-glycerol diesters, (1,3)-glycerol diesters and glycerol triesters are not provided. In view of missing toxicity studies for GEGR, analytical data were submitted to demonstrate that GEGR are chemically equivalent to GEWR which have already been authorised as a food additive by Directive 95/2/EC. Overall, the Panel concluded that the chemical and toxicological characterisation of GEGR is not adequate. The Panel also did not have sufficient information to evaluate the chemical equivalence of GEGR and GEWR on the basis of which the toxicological data obtained with GEWR could be used for read across. Therefore, the Panel concluded that the available data are too limited to conclude on the safety of GEGR as a food additive at the proposed uses and use levels. KEY WORDSGlycerol esters of gum rosin, glycerol-modified gum rosin, CAS Registry Number 8050-31-5. SUMMARYFollowing a request from the European Commission to the European Food Safety Authority (EFSA), the Scientific Panel on Food Additives and Nutrient Sources added to Food (ANS) was asked to provide a scientific opinion on the safety of glycerol esters of gum rosin (GEGR) when used as a stabilising and emulsifying food additive in certain non-alcoholic flavoured cloudy drinks and certain cloudy spirit drinks to a maximum level of 100 mg/l. GEGR have been evaluated by the Joint FAO/WHO Expert Committee on Food Additives (JECFA) in 2009. The Committee established a group ADI of 0 -25 mg/kg bw/day for GEWR (glycerol esters of wood rosin) and GEGR. The specifications for GEGR were made tentative, pending the submission of additional data and information by the end of 2010 concerning the identity of GEGR, the resin acid composition and methods to identify the individual glycerol esters of rosins and their differentiation. Furthermore, the Committee requested the full reports of the two 90-day toxicity studies in rats performed using oral administration of GEGR, to ...

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Hautpflege bei chronisch venöser Insuffizienz

Erfurt‐Berge¹,

Mahler²,

Geier³

2018

Phlebologie

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ZusammenfassungAn Hand von Daten des Informationsverbundes Dermatologischer Kliniken (IVDK) der Jahre 2012–2016 wird das Spektrum von Kontaktsensibilisierungen bei 2011 Patienten mit Ulcus cruris venosum, Stauungsekzem und/oder einem Kontaktekzem bei chronisch venöser Insuffizienz (CVI) beschrieben, und mit dem Sensibilisierungsspektrum einer Kontrollgruppe (n=30 924) im ähnlichen Alter, aber ohne diese Erkrankungen verglichen. Unverändert zu früheren IVDK-Auswertungen zeigten CVI Patienten gehäuft Sensibilisierungen gegen das folgende Allergenspektrum: Perubalsam, Bestandteile von Salbengrundlagen, insbesondere Wollwachsalkohole, Antioxidantien, insbesondere tert-Butylhydrochinon, Kolophonium, Duftstoffe und Parabene. Für die Hautpflege bei entsprechenden Patienten empfehlen sich daher duftstoff- und parabenfreie Produkte ohne Perubalsam (Myroxylon pereirae), Wollwachsalkohole (Lanolin alcohol) und tert-Butylhydrochinon (TBHQ). Dabei ist das sogenannte Parabenund Wollwachs-Paradox zu berücksichtigen: CVI Patienten können an ekzematös veränderter Haut am Unterschenkel auf Parabene oder Wollwachsalkohole reagieren, während diese Stoffe auf normaler Haut an anderen Körperregionen vertragen werden.

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Epikutantestung mit chemisch modifiziertem Kolophonium

Cited by 5 publications

References 3 publications

A clinical and patch test study of patients with positive patch test reactions to fragrance mix in China

A clinical and patch test study of patients with positive patch test reactions to fragrance mix in China

Scientific Opinion on the safety of glycerol esters of gum rosin for the proposed uses as a food additive

Hautpflege bei chronisch venöser Insuffizienz

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