Epilepsia partialis continua in a patient with Behçet's disease

Aktekin, Berrin; Doğan, Ebru Apaydın; Oğuz, Yurttaş; Karaali̇, Kami̇l

doi:10.1016/j.clineuro.2004.12.021

Cited by 11 publications

(8 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…4,5 Epileptic seizures may occur during either the exacerbations or the chronic course of BD as simple or complex partial seizures, myoclonic jerks and generalized tonicclonic seizures. [5][6][7] To our knowledge, there is only one clearly documented report of neuro-BD presenting with seizures, 6 followed later by other CNS manifestations.…”

Section: Discussionmentioning

confidence: 96%

Epileptic seizures as the sole manifestation of neuro-Behçet's disease: Complete control under interferon-alpha treatment

Chroni

Monastirli

Polychronopoulos

et al. 2008

Seizure

View full text Add to dashboard Cite

Behçet's disease (BD) is a multisystemic disease of unknown etiopathogenesis with various clinical features including manifestations from central nervous system involvement. We report the case of a patient presented with a 20-year history of BD and a 10-year history of epileptic seizures refractory to various antiepileptic drugs. Under systemic treatment with interferon-alpha 2a (IFN-alpha) a complete remission of the cutaneous manifestations and a seizure-free state were achieved. The impressive therapeutic response of both the seizures and the non-neurological manifestations to IFN-alpha was also observed upon re-administration of this cytokine subsequent to a severe BD relapse. In view of this response and the lack of any other obvious etiology of the seizures in our patient, it seems reasonable to consider them as being the sole manifestation of neuro-BD. The patient is presently completing a 40-month seizure-free follow-up, despite withdrawal of all antiepileptic drugs for the last 35 months. Further studies on large numbers of patients are now warranted to define the therapeutic efficacy and safety of IFN-alpha in neuro-BD and particularly in neuro-BD-related epileptic seizures.

show abstract

Section: Discussionmentioning

confidence: 96%

Epileptic seizures as the sole manifestation of neuro-Behçet's disease: Complete control under interferon-alpha treatment

Chroni

Monastirli

Polychronopoulos

et al. 2008

Seizure

View full text Add to dashboard Cite

show abstract

“…Similarly, in a Brazilian cohort of 178 Behçet's patients, 40 (22.5%) had neurological involvement, and epilepsy occurred in 7 (17%) of these patients, but only 4% of the overall sample (68). Tonic–clonic seizures predominate, but partial seizures, including epilepsia partialis continua, can occur (64, 69, 70). Cortical vein thrombosis is rarely complicated by seizures, possibly because hemorrhage is not typical (60).…”

Section: Behçet's Diseasementioning

confidence: 99%

Epilepsy Associated with Systemic Autoimmune Disorders

2013

View full text Add to dashboard Cite

Systemic autoimmune disorders affect multiple organ systems. Brain involvement commonly causes seizures, which may be the presenting symptom. Systemic lupus erythematosus, Sjorgren's syndrome, Wegener's granulomatosis, sarcoidsosis, celiac disease, Crohn's disease, Behcet's, and Hashimoto's encephalopathy are reviewed. Mechanisms underlying CNS pathology in systemic autoimmune disorders-and specifically factors predisposing these patients-are discussed, including vascular disease (e.g., prothrombotic state, anticardiolipin antibody, emboli, vasculitis), antineuronal antibodies, immune complexes, cytokines, metabolic disorders, infection, and therapy. Diagnostic and therapeutic strategies must be individualized for both the disorder and the patient. Systemic autoimmune disorders affect multiple organ systems and frequently involve the central and peripheral nervous systems. Seizures are among the most common neurological manifestation and occasionally can be the presenting symptom. There are many causes of seizures in systemic autoimmune disorders (Table 1), and the first clinical challenge is to determine not only the cause but also the significance of seizures. In some cases, they are clues to metabolic or infectious disorders or medication toxicity; in other cases, seizures herald a life-threatening progression of the underlying illness.

show abstract

“…The case of epilepsia partialis continua and recurrent status epilepticus were reported from Turkey [9,10], previously. In our study, one patient had complex partial status epilepticus seven weeks after the diagnosis of CVT.…”

Section: Discussionmentioning

confidence: 87%

“…Epileptic seizure in NBD was observed rarely in previous studies [8,9] Different seizures types such as partial seizures, generalized tonic clonic seizures; myoclonic jerks, epilepsia partialis continua and status epilepticus were reported [8][9][10][11][12]. The aim of this study is to investigate the frequency, type and prognosis of epileptic seizures in different forms of NBD.…”

Section: Introductionmentioning

confidence: 96%