Epilepsie und autonome Störungen

Hilz, M. J.; Dütsch, Matthias; Kölsch, C

doi:10.1055/s-2007-993981

Cited by 10 publications

(3 citation statements)

References 77 publications

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“…Temporal lobe epilepsy (TLE) is well known to be associated with autonomic nervous system dysfunctions [ 1 , 2 ]. Seizures alter the function of different systems such as the respiratory, gastrointestinal, urogenital, and, most importantly, cardiovascular system [ 1 , 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Cerebral Hemispheric Lateralization Associated with Hippocampal Sclerosis May Affect Interictal Cardiovascular Autonomic Functions in Temporal Lobe Epilepsy

Ghchime¹,

Benjelloun

H³

et al. 2016

Epilepsy Research and Treatment

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It is well established that the temporal lobe epilepsy (TLE) is linked to the autonomic nervous system dysfunctions. Seizures alter the function of different systems such as the respiratory, cardiovascular, gastrointestinal, and urogenital systems. The aim of this work was to evaluate the possible factors which may be involved in interictal cardiovascular autonomic function in temporal lobe epilepsy with complex partial seizures, and with particular attention to hippocampal sclerosis. The study was conducted in 30 patients with intractable temporal lobe epilepsy (19 with left hippocampal sclerosis, 11 with right hippocampal sclerosis). All subjects underwent four tests of cardiac autonomic function: heart rate changes in response to deep breathing, heart rate, and blood pressure variations throughout resting activity and during hand grip, mental stress, and orthostatic tests. Our results show that the right cerebral hemisphere predominantly modulates sympathetic activity, while the left cerebral hemisphere mainly modulates parasympathetic activity, which mediated tachycardia and excessive bradycardia counterregulation, both of which might be involved as a mechanism of sudden unexpected death in epilepsy patients (SUDEP).

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Section: Introductionmentioning

confidence: 99%

Cerebral Hemispheric Lateralization Associated with Hippocampal Sclerosis May Affect Interictal Cardiovascular Autonomic Functions in Temporal Lobe Epilepsy

Ghchime¹,

Benjelloun

H³

et al. 2016

Epilepsy Research and Treatment

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“…Moreover, ictal cardiovascular phenomena are among the most common autonomic manifestations of epilepsy (4). Epileptic activity with origin in amygdala, gyrus cinguli, insular cortex, or frontopolar and frontoorbital regions can produce a spectrum of cardiac abnormalities, among them supraventricular tachycardia, sinus tachycardia, sinus bradycardia, sinus arrest, atrioventricular block, and asystole (5).…”

mentioning

confidence: 99%

Cardiac Asystole in Epilepsy: Clinical and Neurophysiologic Features

Rocamora¹,

Kurthen²,

et al. 2003

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Summary: Purpose: Cardiac asystole provoked by epileptic seizures is a rare but important complication in epilepsy and is supposed to be relevant to the pathogenesis of sudden unexplained death in epilepsy (SUDEP). We sought to determine the frequency of this complication in a population of patients with medically intractable epilepsy and to analyze the correlation between EEG, electrocardiogram (ECG), and clinical features obtained from long‐term video‐EEG monitoring.Methods: Retrospective analysis of the clinical records of hospitalized patients from May 1992 to June 2001 who underwent long‐term video‐/EEG monitoring.Results: Of a total of 1,244 patients, five patients had cardiac asystole in the course of ictal events. In these patients, 11 asystolic events, between 4 and 60 s long in a total of 19 seizures, were registered. All seizures had a focal origin with simple partial seizures (n = 13), complex partial seizures (n = 4), and secondarily generalized seizures (n = 2). One patient showed the longest asystole ever reported (60 s) because of a seizure. Cardiac asystole occurred in two patients with left‐sided temporal lobe epilepsy (TLE) and in three patients with frontal lobe epilepsy (FLE; two left‐sided, one bifrontal). Two patients reported previous cardiac disease, but only one had a pathologic ECG by the time of admission. Two patients had a simultaneous central ictal apnea during the asystole. None of the patients had ongoing deficits due to the asystole.Conclusions: These findings confirm that seizure‐induced asystole is a rare complication. The event appeared only in focal epilepsies (frontal and temporal) with a lateralization to the left side. A newly diagnosed or known cardiac disorder could be a risk factor for ictal asystole. Abnormally long postictal periods with altered consciousness might point to reduced cerebral perfusion during the event because of ictal asystole. Central ictal apnea could be a frequent associated phenomenon.

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“…[1] The increase in the heart rate (HR) and blood pressure (BP) frequently precede or accompany discharges during the ictal phase, while decrease in heart rate and blood pressure are rather rare. [2] A 35-year-old female presented to medicine ICU in unconscious state and was found to be in same state by relatives. No history of fever, seizures, consumption of any poison or drug abuse.…”

mentioning

confidence: 99%