Epilepsy and attention deficit hyperactivity disorder: Is methylphenidate safe and effective?

Gross‐Tsur, Varda; Manor, Orly; Meere, van der Jacob; Joseph, Alain; Shalev, Ruth S.

doi:10.1016/s0022-3476(97)70308-1

Cited by 108 publications

(62 citation statements)

References 9 publications

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“…8 A more recent review concludes that the addition of methylphenidate is safe in children with attention-deficit hyperactivity disorder and epilepsy whose seizures are controlled with antiepileptic medication. 15,19 The present study shows that low-dose stimulant medication in children with attention-deficit disorder does not increase the incidence of epileptiform discharges. In another study, the use of methylphenidate in nonepileptic patients with attentiondeficit hyperactivity disorder actually demonstrated normalization of the EEG, behavior, and cognitive function.…”

Section: Localization Of Eeg Abnormalitiesmentioning

confidence: 50%

Frequency of Epileptiform Discharges in the Sleep-Deprived Electroencephalogram in Children Evaluated for Attention-Deficit Disorders

2010

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The authors determined the frequency of epileptiform discharges in the electroencephalogram (EEG) of a cohort of children and adolescents referred to a neurology specialty clinic for evaluation of attention-deficit disorders. Of 624 records, 461 (73.9%) were normal and 163 (26.1%) abnormal. Of abnormal EEGs, 70 (42.9%) had focal epileptiform discharges only, 68 (41.7%) had generalized epileptiform discharges only, and 19 (11.6%) had both independent focal and generalized spikes. Focal spikes were localized chiefly in central, frontal, and temporal regions. Of 163 records with abnormalities, 154 (94.5%) were sleep deprived and 159 (97.5%) were sleep records. One-quarter of the nonepileptic children evaluated for attention-deficit disorder have epileptiform discharges in the EEG, and just more than half are focal. Sleep-deprived sleep is essential to exclude epileptiform abnormalities. The utility of the EEG in the management of attention-deficit disorders and selection of stimulant or nonstimulant medication deserves further study.

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Section: Localization Of Eeg Abnormalitiesmentioning

confidence: 50%

Frequency of Epileptiform Discharges in the Sleep-Deprived Electroencephalogram in Children Evaluated for Attention-Deficit Disorders

2010

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“…18 Methylphenidate has also been shown to be beneficial in ADHD, complicating other neurologic disorders such as mental retardation, fragile X syndrome, pervasive developmental disorder, and epilepsy. 6,7,[19][20][21] To the best of our knowledge, there are no reports on the use of methylphenidate specifically in children with cerebral palsy and ADHD. In fact, recent reviews on the use of methylphenidate did not include cerebral palsy as a comorbid condition to ADHD, 8,22,23 which is somewhat unexpected considering the prevalence of ADHD in other developmental and acquired neurologic disorders.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Methylphenidate in Patients With Cerebral Palsy and Attention-Deficit Hyperactivity Disorder (ADHD)

et al. 2002

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Our objective was to study the short-term efficacy and safety of methylphenidate in patients with the dual diagnosis of cerebral palsy and attention-deficit hyperactivity disorder (ADHD). Twenty-nine patients (8.0 +/- 4.0 years old) with cerebral palsy and ADHD completed the study. In a prospective, crossover, double-blind paradigm, patients were treated with methylphenidate or placebo, each for 4 weeks. Parents and teachers completed a modified Abbreviated Conners' Rating Scale at the beginning of the study and the end of the first and second months of treatment with methylphenidate or placebo. Parents were contacted weekly to report side effects. Methylphenidate treatment, as assessed by teachers' ratings, resulted in a significant improvement in ADHD symptomatology (t = 2.29, df = 27, P < .05); however, a trend for improvement was noted only on the parents' ratings. After the conclusion of the study, 12 patients continued methylphenidate for 20 +/- 10 months. Side effects were minimal, with the exception of transient hallucinations in one patient. In children with cerebral palsy and ADHD, methylphenidate is effective, rendering it a valuable adjunct to their overall medical therapy.

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“…In this study a subgroup of 15 nonepileptic patients had epileptiform EEG at baseline and none of them had a seizure during the study period of 1 year. Several short term studies have reported that MPH is safe to use in both ADHD children with well controlled [25][26][27], and difficult to treat epilepsy [28][29][30], and that 61-73% of children with epilepsy had benefit from MPH. One study reported that use of combination of a behavioral management and MPH 0.3-1 mg/kg/day for 3 months improved ADHD symptoms in 61% of 18 patients with refractory epilepsy [29].…”

Section: Seizure Risk In Adhd Children With Ied and The Use Of Mph Anmentioning

confidence: 99%

Attention deficit/hyperactivity disorder and interictal epileptiform discharges: It is safe to use methylphenidate?

Socanski

Aurlien

Herigstad

et al. 2015

Seizure

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Epilepsy and attention deficit hyperactivity disorder: Is methylphenidate safe and effective?

Cited by 108 publications

References 9 publications

Frequency of Epileptiform Discharges in the Sleep-Deprived Electroencephalogram in Children Evaluated for Attention-Deficit Disorders

Frequency of Epileptiform Discharges in the Sleep-Deprived Electroencephalogram in Children Evaluated for Attention-Deficit Disorders

Efficacy of Methylphenidate in Patients With Cerebral Palsy and Attention-Deficit Hyperactivity Disorder (ADHD)

Attention deficit/hyperactivity disorder and interictal epileptiform discharges: It is safe to use methylphenidate?

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