Epilepsy: Ever-changing states of cortical excitability

Badawy, Radwa A.B.; Freestone, Dean R.; Lai, Alan; Cook, Mark

doi:10.1016/j.neuroscience.2012.07.015

Cited by 78 publications

(72 citation statements)

References 90 publications

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“…One explanation may be the increased variability in cortical excitability during sleep [28], which may originate from an altered functional network organization following sleep deprivation [29]. A mechanism, such as increased synchronization during sleep and after sleep deprivation, may also be a reflection of increased cortical excitability [30,31].…”

Section: Discussionmentioning

confidence: 99%

The role of sleep electroencephalography in patients with new onset epilepsy

Delil

Şenel

Demiray

et al. 2015

Seizure

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Section: Discussionmentioning

confidence: 99%

The role of sleep electroencephalography in patients with new onset epilepsy

Delil

Şenel

Demiray

et al. 2015

Seizure

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“…The core features of the pathophysiology in epilepsy involve disturbed networks resulting in cortical hyperexcitability, supporting the investigation of excitability reducing rTMS as a potential treatment [11,12]. Based on the physics of TMS, either a hyperexcitable epileptogenic focus (EF) is targeted in focal epilepsy or relevant network structures in multifocal or generalized epilepsy, e.g.…”

Section: Downloaded By [Dalhousie University] At 02:14 05 June 2016mentioning

confidence: 99%

Repetitive transcranial magnetic stimulation for the treatment of refractory epilepsy

Carrette

Boon

Dekeyser

et al. 2016

Expert Review of Neurotherapeutics

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This manuscript provides an overview of the performed studies, retrieved from a PubMed search, and a critical appraisal of their results. A number of conclusions are drawn and potential optimization strategies are discussed. Expert commentary: Although the therapeutic efficacy of rTMS in refractory epilepsy has not yet been established, the non-invasiveness of the technique warrants further investigation of rTMS as a treatment for epilepsy.

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“…Second, CCEP data is only assessed in patients with drugresistant epilepsy and it remains unsure if it reflects physiological connectivity. Furthermore, cortical excitability is influenced by multiple factors that cannot all be controlled during the stimulation sessions like vigilance state, sleep debt, menstrual cycle, anxiety level or antiepileptic drugs [44]. Third, the underpinning mechanisms of early and late evoked responses are still incompletely understood as well as the influence of the stimulated and the recorded structure in the response characteristics.…”

Section: Limitationsmentioning

confidence: 99%