Epilepsy in the Renaissance: A survey of remedies from 16th and 17th century German herbals

Adams, Michael; Schneider, Sarah-Vanessa; Kluge, Martin; Kessler, Michael; Hamburger, Matthias

doi:10.1016/j.jep.2012.06.010

Cited by 55 publications

(34 citation statements)

References 77 publications

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“…The Egyptian Papyrus Ebers (c. 1600 BC), clay cuneiforms Tablets from the Ashurbanibal library (c. 650 BC), physicians like Hippocrates (460-377 BC), Galeno , Avicenna (980-1037 DC) and Paracelsus (1493-1541 DC), to name a few, described the therapeutic properties of medicinal herbs in their works. [58][59][60][61][62][63][64][65][66] In some cases, evidences have been based on chemical analyses (Gas chromatography-mass spectroscopy, X-ray spectroscopy, Fourier transform infrared spectroscopy and X-ray powder diffraction) as on Tablets discovered onboard the Pozzino shipwreck (second century BC) 67 and on residues of four medicinal tubes dating form Pliny s era in the collection of the British Museum. 68 However, the use of natural products as therapeutic agents seems to be much older.…”

Section: Pharmacology Of Natural Productsmentioning

confidence: 99%

Research with Chemistry and Pharmacology of Natural Products in Brazil: A Comparison with 70 Selected Countries from 5 Continents

Alves¹,

Pontes²

2017

Rev. Virtual Quim.

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Living organisms (bacteria, fungi, lichens, algae, worms, mushrooms, higher plants, and aquatic and terrestrial animals) produce a plethora of chemical compounds, the natural products , that lie at the heart of an ecological interaction, acting as molecular messengers in defense, attack, sexual attraction, territorial and trail marking, in pollination, as venoms, etc. Eventually, human beings make use of them for their own purposes as food additives, flavoring, cosmetics, fragrances, hallucinogens, in pest control, and as therapeutic agents. The present review compares the participation of Brazilian scientists in the chemistry and pharmacology of natural products with that of other scientists from 69 countries in five continents in 36 selected journals. It also shows the analogy between the Human Development Index (HDI) and the rank of the countries with the number published articles. The search was performed in the Web of Knowledge by cross-selecting the names of each journal with that of each country for the period 1945-2013.Keywords: Brazil; chemistry of natural products; pharmacology of natural products; peer journals. ResumoOrganismos vivos (bactérias, fungos, liquens, vermes, cogumelos, vegetais superiores, e animais aquáticos e terrestres) produzem uma pletora de substâncias químicas, os produtos naturais , que estão no coração de uma interação ecológica, atuando como mensageiros moleculares na defesa, ataque, atração sexual, marcação territorial e de trilha, na polinização, como venenos, etc. Eventualmente, os seres humanos fazem uso deles para o seu próprio benefício como aditivos, flavorizantes, cosméticos, fragrância, alucinógenos, no controle de pestes, e como agentes terapêuticos. Esta revisão compara a participação de cientistas brasileiros na química e farmacologia de produtos naturais com a de cientistas de 69 países de cinco continentes em 36 periódicos selecionados. Ela também mostra a analogia entre o Índice de Desenvolvimento Humano (IDH) e a classificação dos países com o número de artigos publicados. A pesquisa foi realizada na Web of Knowledge através de seleção cruzada do nome de cada periódico com o de cada país no período 1945-2013.Palavras-chave: Brasil; química de produtos naturais; farmacologia de produtos naturais; periódicos.

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Section: Pharmacology Of Natural Productsmentioning

confidence: 99%

Research with Chemistry and Pharmacology of Natural Products in Brazil: A Comparison with 70 Selected Countries from 5 Continents

Alves¹,

Pontes²

2017

Rev. Virtual Quim.

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“…For example, herbal medicine is the most common mode of treatment administered by traditional healers in sub-Saharan Africa [4,[23][24][25]. Herbal medicines are also used for epilepsy in Asia and Central and South America and were the only available form of antiepileptic drug treatment in Europe until the mid-19th century [26]. In fact, herbal medicine is the direct progenitor of modern pharmacotherapy, and some of the most important and successful drugs are derived from natural products [27,28].…”

Section: Drug Treatment Of Epilepsymentioning

confidence: 99%

A pharmacological basis of herbal medicines for epilepsy

Sucher¹,

Carles²

2015

Epilepsy & Behavior

125

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“…In medical systems based on herbalism, folklore, or shamanism, however, no written documents exist, and the herbal formulations used are often kept secret by the practitioners, making the information more difficult to access (Brusotti et al, 2014;Fabricant and Farnsworth, 2001). Depending on the herbs to be studied, information can be acquired from different sources, including books on medical botany (e.g., Lewis, 2003), herbals (e.g., Adams et al, 2012), review articles on medicinal plants used in a certain geographic region or by an ethnic culture (e.g., Gairola et al, 2014), field work (e.g., Kunwar et al, 2009), and computer databases (Leonti, 2011;Ningthoujam et al, 2012).…”

Section: Renewal Of the Interest In Natural Product-based Drug Discoverymentioning

confidence: 99%

Discovery and resupply of pharmacologically active plant-derived natural products: A review

2015

Draw Science

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Medicinal plants have historically proven their value as a source of molecules with therapeutic potential, and nowadays still represent an important pool for the identification of novel drug leads. In the past decades, pharmaceutical industry focused mainly on libraries of synthetic compounds as drug discovery source. They are comparably easy to produce and resupply, and demonstrate good compatibility with established high throughput screening (HTS) platforms. However, at the same time there has been a declining trend in the number of new drugs reaching the market, raising renewed scientific interest in drug discovery from natural sources, despite of its known challenges. In this survey, a brief outline of historical development is provided together with a comprehensive overview of used approaches and recent developments relevant to plant-derived natural product drug discovery. Associated challenges and major strengths of natural product- Europe PMC Funders Author ManuscriptsEurope PMC Funders Author Manuscripts based drug discovery are critically discussed. A snapshot of the advanced plant-derived natural products that are currently in actively recruiting clinical trials is also presented. Importantly, the transition of a natural compound from a "screening hit" through a "drug lead" to a "marketed drug" is associated with increasingly challenging demands for compound amount, which often cannot be met by re-isolation from the respective plant sources. In this regard, existing alternatives for resupply are also discussed, including different biotechnology approaches and total organic synthesis.While the intrinsic complexity of natural product-based drug discovery necessitates highly integrated interdisciplinary approaches, the reviewed scientific developments, recent technological advances, and research trends clearly indicate that natural products will be among the most important sources of new drugs also in the future.

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Epilepsy in the Renaissance: A survey of remedies from 16th and 17th century German herbals

Cited by 55 publications

References 77 publications

Research with Chemistry and Pharmacology of Natural Products in Brazil: A Comparison with 70 Selected Countries from 5 Continents

Research with Chemistry and Pharmacology of Natural Products in Brazil: A Comparison with 70 Selected Countries from 5 Continents

A pharmacological basis of herbal medicines for epilepsy

Discovery and resupply of pharmacologically active plant-derived natural products: A review

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