Epilepsy-Related Brain Network Alterations in Patients With Temporal Lobe Glioma in the Left Hemisphere

Sun, Fang; Zhou, Chunyao; Fan, Xing; Jiang, Tao; Wang, Yinyan

doi:10.3389/fneur.2020.00684

Cited by 17 publications

(29 citation statements)

References 35 publications

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“…Global efficiency was significantly decreased, and the shortest path length was significantly increased in both the insL and insR groups as compared with those in the control group. These findings are consistent with the findings from previous studies 25 – 28 , and indicates that the pathways of information conveying change as DLGGs grow.…”

Section: Discussionsupporting

confidence: 92%

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Contralesional functional network reorganization of the insular cortex in diffuse low-grade glioma patients

Sun

Zhou

Wang

et al. 2021

Sci Rep

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Diffuse low-grade gliomas (DLGGs) growing on the insular lobe induce contralesional hemispheric insular lobe compensation of damaged functioning by increasing cortical volumes. However, it remains unclear how functional networks are altered in patients with insular lobe DLGGs during functional compensation. Thirty-five patients with insular DLGGs were classified into the left (insL, n = 16) and right groups (insR, n = 19), and 33 healthy subjects were included in the control group. Resting state functional magnetic resonance imaging was used to generate functional connectivity (FC), and network topological properties were evaluated using graph theoretical analysis based on FC matrices. Network-based statistics were applied to compare differences in the FC matrices. A false discovery rate was applied to correct the topological properties. There was no difference in the FC of edges between the control and insL groups; however, the nodal shortest path length of the right insular lobe was significantly increased in the insL group compared to the control group. Additionally, FC was increased in the functional edges originating from the left insular lobe in the insR group compared to the control group. Moreover, there were no differences in topological properties between the insR and control groups. The contralesional insular lobe is crucial for network alterations. The detailed patterns of network alterations were different depending on the affected hemisphere. The observed network alterations might be associated with functional network reorganization and functional compensation.

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Section: Discussionsupporting

confidence: 92%

“…The one is that contralesional insula participated in functional network reorganizations. Since, the glioma is commonly thought to disrupt functional networks and decrease FC 25,32,33 . Hence, the increasing FC implied that network reorganization occurred similar to what other studies have shown 3,10,19,20 .…”

Section: Discussionmentioning

confidence: 99%

Contralesional functional network reorganization of the insular cortex in diffuse low-grade glioma patients

Sun

Zhou

Wang

et al. 2021

Sci Rep

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“…A software, Graph Theoretical Network Analysis (https://www.nitrc.org/projects/gretna), 12,13 was used to process rs‐fMRI data. The pipeline was the same as in the previous study 10 and is shown in the Appendix S1.…”

Section: Methodsmentioning

confidence: 99%

“…Topological properties of the four sub‐networks were analyzed using graph theory measurement, which included global properties (the shortest path length, global efficiency, local efficiency, clustering coefficient, transitivity, and vulnerability), nodal properties (nodal efficiency, nodal local efficiency, nodal clustering coefficient, degree centrality), and small‐worldness 10,15,16 . The details of properties were shown in part 2 of the Appendix S1.…”

Section: Methodsmentioning

confidence: 99%

“…Hence, previous conclusions based on primary seizures are not applicable in patients with glioma and may occlude appropriate preoperative prevention and intraoperative treatment. Although left temporal gliomas were found to activate visual networks and GRE to inhibit visual networks, 10 it remains unknown whether right temporal gliomas and GRE cause the same changes. Consequently, further investigation of how the glioma in right temporal lobe and GRE impact neural networks is important to optimize strategies of preoperative seizure control and intraoperative treatment.…”

Section: Introductionmentioning

confidence: 99%

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Epilepsy enhance global efficiency of language networks in right temporal lobe gliomas

2021

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Aims We analyzed the resting state functional magnetic resonance images to investigate the alterations of neural networks in patients with glioma‐related epilepsy (GRE). Methods Fifty‐six patients with right temporal lower‐grade glioma were divided into GRE (n = 28) and non‐GRE groups. Twenty‐eight healthy subjects were recruited after matching age, sex, and education level. Sensorimotor, visual, language, and left executive control networks were applied to generate functional connectivity matrices, and their topological properties were investigated. Results No significant alterations in functional connectivity were found. The least significant discovery test revealed differences only in the language network. The shortest path length, clustering coefficient, local efficiency, and vulnerability were greater in the non‐GRE group than in the other groups. The nodal efficiencies of two nodes (mirror areas to Broca and Wernicke) were weaker in the non‐GRE group than in the other groups. The node of degree centrality (Broca), nodal local efficiency (Wernicke), and nodal clustering coefficient (temporal polar) were greater in the non‐GRE group than in the healthy group. Conclusion Different tumor locations alter different neural networks. Temporal lobe gliomas in the right hemisphere altered the language network. Glioma itself and GRE altered the network in opposing ways in patients with right temporal glioma.

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Increasing nodal vulnerability and nodal efficiency implied recovery time prolonging in patients with supplementary motor area syndrome

Sun

Weng

et al. 2022

Human Brain Mapping

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Supplementary motor area (SMA) syndrome is a surgery‐related complication that commonly occurs after removing SMA glioma, and needs weeks to recover. However, susceptible factors of patients suffering from SMA syndrome remain unknown. Graphic theory was applied to reveal topological properties of sensorimotor network (SMN) by processing resting‐state functional magnetic resonance images in 66 patients with SMA gliomas. Patients were classified into SMA and non‐SMA groups based on whether they suffered from SMA syndrome. We collected recovery time and used causal mediation analysis to find association between topological properties and recovery time. Compared with the non‐SMA group, higher vulnerability (left: p = .0018; right: p = .0033) and lower fault tolerance (left: p = .0022; right: p = .0248) of the whole SMN were found in the SMA group. Moreover, higher nodal properties of lesional‐hemispheric cingulate cortex (nodal efficiency: left, p = .0389; right, p = .0169; nodal vulnerability: left, p = .0185; right, p = .0085) and upper limb region of primary motor cortex (PMC; nodal efficiency: left, p = .0132; right, p = .0001; nodal vulnerability: left, p = .0091; right, p = .0209) were found in the SMA group. Nodal efficiency and nodal vulnerability of cingulate cortex and upper limb region of PMC were important predictors for SMA syndrome occurring and recovery time prolonging. Neurosurgeons should carefully deal with upper limb region of PMC and cingulate cortex, and protect them if these two region were unnecessary to damage during SMA glioma resection.

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Epilepsy-Related Brain Network Alterations in Patients With Temporal Lobe Glioma in the Left Hemisphere

Cited by 17 publications

References 35 publications

Contralesional functional network reorganization of the insular cortex in diffuse low-grade glioma patients

Contralesional functional network reorganization of the insular cortex in diffuse low-grade glioma patients

Epilepsy enhance global efficiency of language networks in right temporal lobe gliomas

Increasing nodal vulnerability and nodal efficiency implied recovery time prolonging in patients with supplementary motor area syndrome

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