Epilepsy, the Cerebellum, and Cerebellar Stimulation

Brice, Jason; McLellan, D L; Wright, G D

doi:10.1016/s0140-6736(83)90846-2

Cited by 2 publications

(1 citation statement)

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“…The first reported use of electrical stimulation for the treatment of seizures in humans was in 1973 and involved placement of electrode pads directly over the superiomedial surface of the cerebellar hemispheres in epileptic patients [1]. Early evidence suggested that this strategy was efficacious, with nearly 60% reduction in seizure frequency and a seizure freedom rate of approximately 30% [2][3][4][5][6][7][8]. However, two subsequent controlled studies on a combined 17 patients later showed that cerebellar stimulation made no significant difference in seizure outcomes [9,10], resulting in the eventual abandonment of the cerebellum as a stimulation target for seizures.…”

Section: Introductionmentioning

confidence: 99%

White matter stimulation for the treatment of epilepsy

Girgis

Miller

2016

Seizure

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Electrical stimulation in the treatment of epilepsy has been tried in numerous forms and with a variety of targets. Some of these, such as anterior thalamic stimulation, responsive cortical stimulation, and vagal nerve stimulation, have shown promise. A relatively novel concept, that of white matter stimulation, offers a different mechanism in that a small population of stimulated axons can transmit current to a large population of epileptogenic neurons. In theory, this allows for the modulation of seizure circuits and neural networks using lower stimulation volumes. Although clinical data is currently sparse, we review the relevant studies pertaining to white matter stimulation in epilepsy thus far, and offer explanations as to its effects, potential advantages, and utility.

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