Epilepsy—Work-Up and Management in Children

Tenney, Jeffrey R.

doi:10.1055/s-0040-1718720

Cited by 12 publications

(4 citation statements)

References 86 publications

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“…Epilepsy is a neurological disorder characterized by abnormal neural discharges in the brain, with a lifelong risk of 1-3% in children [1] . While most children with epilepsy respond well to antiepileptic drugs and cease to have seizures, approximately 30% continue to experience seizures despite taking multiple antiepileptic drugs, known as refractory epilepsy [2,3] .…”

Section: Introductionmentioning

confidence: 99%

Study on the Effects of a Ketogenic Diet Full-Cycle Management Platform in Children with Refractory Epilepsy

Wang,

Ye,

Tian

et al. 2024

Preprint

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Objective: To develop and explore the application effects of a Ketogenic Diet Full-Cycle Management Platform in the nursing care of children with refractory epilepsy undergoing a ketogenic diet. Methods: A prospective, non-synchronous control study was conducted. Thirty children undergoing a ketogenic diet from August to September 2023 were selected as the control group, while thirty children undergoing the diet from October to November 2023 served as the experimental group. The control group received standard nursing care, whereas the experimental group received interventions through the Ketogenic Diet Full-Cycle Management Platform, on top of the control group's regimen. The study compared the average daily seizure frequency, the average daily incidence of adverse reactions, and the average duration of the ketogenic diet between the two groups after four weeks. Results: The experimental group showed a decrease in seizure frequency and adverse reactions, along with an increased average duration of the ketogenic diet compared to the control group. These findings were statistically significant (P < 0.05). Conclusion: The Ketogenic Diet Full-Cycle Management Platform enables parents of affected children to more conveniently and quickly grasp the knowledge related to the ketogenic diet. Medical staff can timely understand changes in the children's diet through the platform, make adjustments as needed, and thus improve the quality and effectiveness of the ketogenic diet for children with refractory epilepsy.

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Section: Introductionmentioning

confidence: 99%

Study on the Effects of a Ketogenic Diet Full-Cycle Management Platform in Children with Refractory Epilepsy

Wang,

Ye,

Tian

et al. 2024

Preprint

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“…Treatment for epilepsy aims to control seizures, improve patients’ quality of life, and prevent epilepsy-related morbidity and mortality. 18 Today, anti-epileptic drugs (AED) with various mechanisms of action are used to treat epilepsy. 19 , 20 Despite receiving the best medical care possible and the most potent AEDs, about one-third of children with epilepsy still experience seizures.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of MicroRNAs in Pediatric Epilepsy

Çarman¹,

Tekin²,

Çavuşoğlu³

et al. 2023

Turkish Archives of Pediatrics

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Objective: The pathophysiology of epilepsy remains unknown. Recent research has shown that microRNA expression changes in epileptic adults. In the present work, we aimed to identify serum microRNA expression in drug-responsive and resistant children with idiopathic generalized epilepsy. Materials and Methods: The study included 43 (20 male and 23 female) epilepsy patients and 66 (43 male and 23 female) control subjects. The mean ages of the groups were 113.41 ± 61.83 and 105.46 ± 62.31 months, respectively. Twenty-eight epileptic patients were classified as drug resistant. Thirteen of the controls were the siblings of patients with epilepsy. The study only included children with idiopathic generalized epilepsy who had normal brain magnetic resonance imaging. The serum microRNA expressions (microRNA-181a, microRNA-155, microRNA-146, and microRNA-223) were investigated. Expressions of serum microRNA-181a, microRNA-155, microRNA-146, and microRNA-223 were previously investigated in epilepsy patients and children with febrile seizures. Therefore, these microRNAs were chosen. The expressions of serum levels of microRNAs were determined using quantitative real-time polymerase chain reaction. Results: The results indicated that the expressions of serum microRNA-155 and microRNA-223 were elevated in epileptic children ( P < .05). The expression of the same microRNAs was also elevated in individuals with drug-resistant epilepsy compared to healthy controls ( P < .05). microRNA-146a, microRNA-155, and microRNA-223 expressions were higher in drug-resistant patients than in drug-responsive children ( P < .05). A logistic regression study determined that an increase of microRNA-155 was a risk for epilepsy, while a decrease of microRNA-146a risk for epilepsy. Conclusion: Few researchers have investigated the function of microRNAs in the development of childhood epilepsy. Our findings revealed that epilepsy patients have abnormal microRNAexpression.

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“…According to statistics, pediatric epilepsy (PE) affects the health of 65 million children worldwide. The prevalence of PE ranges from 3.2/1,000 to 6.3/1,000 in developed countries and 5/1,000 in China (1)(2)(3). PE primarily affects children under the age of seven, with the highest incidence occurring within the first year of life (4).…”

Section: Introductionmentioning

confidence: 99%

Identification of miRNAs in extracellular vesicles as potential diagnostic markers for pediatric epilepsy and drug-resistant epilepsy via bioinformatics analysis

Ruan,

Deng,

Liu

et al. 2023

Front. Pediatr.

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BackgroundPediatric epilepsy (PE) is a common neurological disease. However, many challenges regarding the clinical diagnosis and treatment of PE and drug-resistant epilepsy (DRE) remain unsettled. Our study aimed to identify potential miRNA biomarkers in children with epilepsy and drug-resistant epilepsy by scrutinizing differential miRNA expression profiles.MethodsIn this study, miRNA expression profiles in plasma extracellular vesicles (EV) of normal controls, children with drug-effective epilepsy (DEE), and children with DRE were obtained. In addition, differential analysis, transcription factor (TF) enrichment analysis, Gene ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses, and target gene prediction were used to identify specifically expressed miRNAs and their potential mechanisms of action. Potential diagnostic markers for DRE were identified using machine learning algorithms, and their diagnostic efficiency was assessed by the receiver operating characteristic curve (ROC).ResultsThe hsa-miR-1307-3p, hsa-miR-196a-5p, hsa-miR-199a-3p, and hsa-miR-21-5p were identified as diagnostic markers for PE, with values of area under curve (AUC) 0.780, 0.840, 0.832, and 0.816, respectively. In addition, the logistic regression model incorporating these four miRNAs had an AUC value of 0.940, and its target gene enrichment analysis highlighted that these miRNAs were primarily enriched in the PI3K-Akt, MAPK signaling pathways, and cell cycle. Furthermore, hsa-miR-99a-5p, hsa-miR-532-5p, hsa-miR-181d-5p, and hsa-miR-181a-5p showed good performance in differentiating children with DRE from those with DEE, with AUC values of 0.737 (0.534–0.940), 0.737 (0.523–0.952), 0.788 (0.592–0.985), and 0.788 (0.603–0.974), respectively.ConclusionThis study characterized the expression profile of miRNAs in plasma EVs of children with epilepsy and identified miRNAs that can be used for the diagnosis of DRE.

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Epilepsy—Work-Up and Management in Children

Cited by 12 publications

References 86 publications

Study on the Effects of a Ketogenic Diet Full-Cycle Management Platform in Children with Refractory Epilepsy

Study on the Effects of a Ketogenic Diet Full-Cycle Management Platform in Children with Refractory Epilepsy

Evaluation of MicroRNAs in Pediatric Epilepsy

Identification of miRNAs in extracellular vesicles as potential diagnostic markers for pediatric epilepsy and drug-resistant epilepsy via bioinformatics analysis

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