Epileptic seizure-induced hypertension and its prevention by calcium channel blockers: a real-time study in conscious telemetered rats

Beig, Mirza Irfan; Chandra, Ramesh; Talwar, Anita; Fahim, Mohammad; Katyal, Anju

doi:10.1139/y09-034

Cited by 6 publications

(4 citation statements)

References 33 publications

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“…Unlike most reported human heart rate changes, our results showed that the PTZ induced seizures did not cause an increase of heart rate while ictal events happened. This observation was consistent with a previous report (Randall and Rohse 1956), but contradictory to other reports in terms of PTZ effects (Auerbach et al 2013;Beig et al 2009). Since our experiments were done with Xenopus in anesthesia, the effects of anesthetic drugs should be investigated.…”

Section: Cardiac and Cerebral Influences Caused By Chemical Induced Epilepsysupporting

confidence: 89%

Simultaneous Cardiac and Neurological Monitoring to Assess Chemical Exposures and Drug Toxicity in Xenopus Laevis

Xia

Zhang

Vishwanath

et al. 2021

Preprint

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Simultaneous monitoring of electrocardiogram (ECG) and electroencephalogram (EEG) under chemical exposure requires innovative engineering techniques that can capture minute physiological changes in studied animal models. However, this is often administered with a bulky system that may cause signal distortions and discomfort for animals. We develop an integrated bioelectronic sensing system to provide simultaneous ECG and EEG assessment in real-time under chemical exposure for Xenopus laevis. The microelectrode array (MEA) membrane with integrated ECG and EEG sensing offers an opportunity to achieve multichannel noninvasive electrophysiological monitoring with favorable dimensions and spatial resolution. To validate the performance of our system, we assessed the ECG and EEG of Xenopus under exposure of Pentylenetetrazol (PTZ), an epilepsy-inducing drug. Effects of PTZ were detected with clear ECG and EEG alterations, including frequent ictal and interictal EEG events, 30 dB average EEG amplitude elevations, abnormal ECG morphology, and heart rate changes. Overall, our Xenopus-based real-time electrophysiology monitoring system holds high potential for many applications in drug screening and remote environmental toxicity monitoring.

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Section: Cardiac and Cerebral Influences Caused By Chemical Induced Epilepsysupporting

confidence: 89%

Simultaneous Cardiac and Neurological Monitoring to Assess Chemical Exposures and Drug Toxicity in Xenopus Laevis

Xia

Zhang

Vishwanath

et al. 2021

Preprint

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“…Hypertension is a major health problem in which the blood pressure in the arteries is chronically elevated. One of its causes may be changes in autonomic functions which also brings about epileptic seizures [42]. Hypertension is usually not identified by any symptom, and is detected through screening when the patient visits to physician for an unrelated problem.…”

Section: Resultsmentioning

confidence: 99%

An Ultra-sensitive LC Method for the Simultaneous Determination of Paracetamol, Carbamazepine, Losartan and Ciprofloxacin in Bulk Drug, Pharmaceutical Formulation and Human Serum by Programming the Detector

Sultana¹,

Arayne²,

Ali³

2013

AJAC

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An ultra-sensitive LC method for the simultaneous quantitation of paracetamol, carbamazepine, losartan and ciprofloxacin have been developed and validated following the ICH guidelines at isobestic point and by programming the detector at individual wavelength of each component. −1 respectively. Percent recoveries > 98.37% from pharmaceutical formulation and human serum samples and RSD < 2% for inter-day and intra-day assay were obtained. The method was found to be robust and can be successfully applied for the determination of studied drugs in, pharmaceutical formulations and human serum without interference of excipients or endogenous components of serum.

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“…Seizures directly affect HR, mean arterial pressure (MAP), respiration and cardiac function, while autonomic dysfunction also occur interictally in chronic epilepsy (Brewster et al 2016). MAP increased and HR decreased during PTZ-induced seizures at the >3 seizure stage (Beig et al 2009). Seizures frequently cause transient increases in HR and BP; however, it is not clear whether having active epilepsy can also affect these vital signs interictally.…”

Section: Discussionmentioning

confidence: 99%

Polish Journal of Veterinary Sciences

Kapucu

Üstünova

Akgün-Dar

2020

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Nitric oxide (NO) is known to be a neuromodulator with dual proconvulsive and anticonvulsive action. Valeriana officinalis (VAL) was previously believed to be antiepileptic, but is today known as a sedative and sleep regulator. Seizures may be associated with abnormal electrocardiographic changes and cardiac dysfunction arising from epilepsy may be related with neuronal nitric oxide (nNO). This study was aimed to investigate the effects of the neuronal nitric oxide synthase (nNOS) inhibitor 7-Nitroindazole (7-NI) and VAL on seizure behaviours and electrocardiographic parameters in the pentylentetrazole (PTZ)-kindled seizure model.Wistar rats were randomised into saline control, PTZ-kindled, 7-NI, VAL and VAL+PTZ, 7-NI+PTZ and VAL+7-NI+PTZ groups. Latency, stage, frequency of seizures, blood pressure (BP), heart rate (HR) and corrected QT (QTc) values were evaluated.Frequency and stage of seizures, BP and HR increased, while seizure latency decreased and QTc was prolonged in the PTZ-kindled group. 7-NI and VAL had no effects on BP and HR variables under normal conditions, but ameliorated the seizure stage and frequency of seizures. 7-NI treatment also resulted in a reduction of the increased BP and prolonged QTc values observed in PTZ-kindled rats.Considering these results, QTc prolongation may be used as a predictor for recurrent seizures. 7-NI and VAL exhibited different effects on seizures and ECG variables. 7-NI shows potential as an anticonvulsant drug agent in epileptic patients with cardiac dysfunctions and those additional studies including in-vivo experiments are essential.

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Epileptic seizure-induced hypertension and its prevention by calcium channel blockers: a real-time study in conscious telemetered rats

Cited by 6 publications

References 33 publications

Simultaneous Cardiac and Neurological Monitoring to Assess Chemical Exposures and Drug Toxicity in Xenopus Laevis

Simultaneous Cardiac and Neurological Monitoring to Assess Chemical Exposures and Drug Toxicity in Xenopus Laevis

An Ultra-sensitive LC Method for the Simultaneous Determination of Paracetamol, Carbamazepine, Losartan and Ciprofloxacin in Bulk Drug, Pharmaceutical Formulation and Human Serum by Programming the Detector

Polish Journal of Veterinary Sciences

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