Epileptiform burst responses in ventral vs dorsal hippocampal slices

Gilbert, Mary E.; Racine, R.; Smith, Grant K.

doi:10.1016/0006-8993(85)91309-5

Cited by 119 publications

(73 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Mean amplitude of evoked potentials is higher in slices taken from the temporal pole of the hippocampus at baseline conditions (Gilbert et al 1985;Maggio and Segal 2007). At higher K þ concentrations, epileptiform bursting was induced in all slices, but there was a higher likelihood of burst firing in temporal slices as compared with septal ones (Gilbert et al 1985;Bragdon et al 1986). In contrast, the threshold for long-term potentiation (LTP) induction appears to be lower in slices taken from the septal pole of CA1 (Elul 1964).…”

Section: Electrophysiological Propertiesmentioning

confidence: 89%

Functional Differentiation of Adult-Born Neurons along the Septotemporal Axis of the Dentate Gyrus: Figure 1.

Sahay

Duman

et al. 2015

Cold Spring Harb Perspect Biol

View full text Add to dashboard Cite

Over the past several decades, the proliferation and integration of adult-born neurons into existing hippocampal circuitry has been implicated in a wide range of behaviors, including novelty recognition, pattern separation, spatial learning, anxiety behaviors, and antidepressant response. In this review, we suggest that the diversity in behavioral requirements for new neurons may be partly caused by separate functional roles of individual neurogenic niches. Growing evidence shows that the hippocampal formation can be compartmentalized not only along the classic trisynaptic circuit, but also along a longitudinal septotemporal axis. We suggest that subpopulations of hippocampal adult-born neurons may be specialized for distinct mnemonic-or mood-related behavioral tasks. We will examine the literature supporting a functional and anatomical dissociation of the hippocampus along the longitudinal axis and discuss techniques to functionally dissect the roles of adult-born hippocampal neurons in these distinct subregions.

show abstract

Section: Electrophysiological Propertiesmentioning

confidence: 89%

Functional Differentiation of Adult-Born Neurons along the Septotemporal Axis of the Dentate Gyrus: Figure 1.

Sahay

Duman

et al. 2015

Cold Spring Harb Perspect Biol

View full text Add to dashboard Cite

show abstract

“…Likewise, differences in constitution of the neuronal network are found within the dorsal and ventral regions (Moser and Moser, 1998). In the ventral hippocampal formation in rodents the density of dopaminergic, noradrenergic, and serotonergic terminals is higher (Gage and Thompson, 1980) and neurons have a significantly greater tendency to generate multiple population spikes than in the dorsal hippocampal formation (Gilbert et al, 1985). Other evidence from electrophysiological studies in both rats (Jung et al, 1994) and primates (Colombo et al, 1998) and from structural magnetic resonance imaging studies (Kjelstrup et al, 2002) furthermore suggest functional dissociation between the dorsal and ventral hippocampal formation.…”

Section: Discussionmentioning

confidence: 99%

Hippocampal Cytogenesis Correlates to Escitalopram-Mediated Recovery in a Chronic Mild Stress Rat Model of Depression

Jayatissa

Bisgaard

Tingström

et al. 2006

Neuropsychopharmacol

325

205

View full text Add to dashboard Cite

From clinical studies it is known that recurrent depressive episodes associate with a reduced hippocampal volume. Conversely, preclinical studies have shown that chronic antidepressant treatment increases hippocampal neurogenesis. Consequently, it has been suggested that a deficit in hippocampal neurogenesis is implicated in the pathophysiology of depression. To study a potential correlation between recovery and hippocampal cytogenesis, we established the chronic mild stress (CMS) rat model of depression. When rats are subjected to CMS, several depressive symptoms develop, including the major symptom anhedonia. Rats were exposed to stress for 2 weeks and subsequently to stress in combination with antidepressant treatment for 4 consecutive weeks. The behavioral deficit measured in anhedonic animals is a reduced intake of a sucrose solution. Prior to perfusion animals were injected with bromodeoxyuridine (BrdU), a marker of proliferating cells. Brains were sectioned horizontally and newborn cells positive for BrdU were counted in the dentate gyrus and tracked in a dorsoventral direction.CMS significantly decreased sucrose consumption and cytogenesis in the ventral part of the hippocampal formation. During exposure to the antidepressant escitalopram, given as intraperitoneally dosages of either 5 or 10 mg/kg/ day, animals distributed in a bimodal fashion into a group, which recovered (increase in sucrose consumption), and a subgroup, which refracted treatment (no increase in sucrose consumption). Chronic treatment with escitalopram reversed the CMS-induced decrease in cytogenesis in the dentate gyrus of the ventral hippocampal formation, but in recovered animals only. Our data show a correlation between recovery from anhedonia, as measured by cessation of behavioral deficits in the CMS model, and an increase in cytogenesis in the dentate gyrus of the ventral hippocampal formation.

show abstract

“…When stimulating the SN, on the other hand, inhibition appeared less profound in the ventral hippocampus than in the dorsal region. It is interesting to note that the ventral hippocampus has been shown to be more prone to epileptiform activity (Gilbert, Racine Smith, 1985) and in an in vitro study the ventral hippocampus expressed significantly less synaptic inhibition than the dorsal hippocampus (Radpour & Wheal, 1987).…”

Section: Discussionmentioning

confidence: 99%

Synaptic inhibition in the rat hippocampus in vivo following stimulation of the substantia nigra and ventral tegmentum.

Spencer

Wheal

1990

The Journal of Physiology

View full text Add to dashboard Cite

SUMMARY1. The effects of stimulating the substantia nigra (SN) or the ventral tegmental area (VTA) on the excitability of cells in the rat hippocampal formation have been investigated in vivo.2. A train of conditioning stimuli to either of the midbrain nuclei produced inhibition of evoked population spikes recorded in the CAI pyramidal cell layer of the hippocampus.3. These trains of pulses had no effect on the evoked synaptic field potential recorded in the stratum radiatum although they were effective in suppressing glutamate-induced firing of cells in the hippocampus. These observations suggest that the inhibition is mediated through a postsynaptic mechanism.4. The inhibition of the test population spike was observed at a latency of 50 ms after the conditioning train to either the SN or the VTA but did not reach a maximum until 300-500 ms and 500-750 ms post-conditioning, respectively. The total duration of the inhibition in each case was about 5 s.5. Following stimulation of the VTA, comparable levels of inhibition were recorded in the ventral and dorsal hippocampus. However, after stimulation of the SN, significantly less inhibition was observed in the ventral hippocampus.6. Unlike the effects on the commissural-evoked population spike in CAL, stimulation of SN or VTA had no effect on perforant path-induced granule cell excitability in the dentate gyrus.7. These results suggest that activity in the substantia nigra or ventral tegmental areas could have a powerful regulatory or feedback role in suppressing hippocampal excitability.

show abstract

Epileptiform burst responses in ventral vs dorsal hippocampal slices

Cited by 119 publications

References 8 publications

Functional Differentiation of Adult-Born Neurons along the Septotemporal Axis of the Dentate Gyrus: Figure 1.

Functional Differentiation of Adult-Born Neurons along the Septotemporal Axis of the Dentate Gyrus: Figure 1.

Hippocampal Cytogenesis Correlates to Escitalopram-Mediated Recovery in a Chronic Mild Stress Rat Model of Depression

Synaptic inhibition in the rat hippocampus in vivo following stimulation of the substantia nigra and ventral tegmentum.

Contact Info

Product

Resources

About