Epileptiform lesions in rat hippocampus and acquisition of two-way avoidance☆

Woodruff, Michael L.; Fish, Barbara Schneiderman; Alderman, Alan O.

doi:10.1016/0031-9384(77)90286-4

Cited by 39 publications

(2 citation statements)

References 14 publications

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“…Because during two-way active avoidance training rats receive shocks in two different locations, learning the locations in which it occurs may inhibit the action of returning to that location. This hypothesis is supported by reports of improved learning of two-way active avoidance in rats with a lesion in the hippocampus or related structures (Torras-Garcia et al 2003;Woodruff et al 1977). At the same time, the increased release of DA in the dorsomedial striatum (DMS) adds flexibility to the action-selection due to projections from the prefrontal cortex (PFC) to the DMS (Ragozzino et al 2002;.…”

Section: Discussionmentioning

confidence: 85%

Roles of D1-like dopamine receptors in the nucleus accumbens and dorsolateral striatum in conditioned avoidance responses

Wietzikoski¹,

Boschen²,

Miyoshi

et al. 2011

Psychopharmacology

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Section: Discussionmentioning

confidence: 85%

Roles of D1-like dopamine receptors in the nucleus accumbens and dorsolateral striatum in conditioned avoidance responses

Wietzikoski¹,

Boschen²,

Miyoshi

et al. 2011

Psychopharmacology

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“…The animals used in experiments do not have diseased brains and, therefore, do not show a postlesion memory impairment. This hypothesis has intuitive appeal and has received some empirical support (Isaacson 1972b), but recent evidence makes it difficult to accept (Woodruff, Fish, and Alderman 1977).…”

Section: Department Of Anatomy College Of Medicine East Tennessee Smentioning

confidence: 99%

Hippocampus, space, and memory

1979

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We examine two different descriptions of the behavioral functions of the hippocampal system. One emphasizes spatially organized behaviors, especially those using cognitive maps. The other emphasizes memory, particularly working memory, a short-term memory that requires iexible stimulus-response associations and is highly susceptible to interference. The predictive value of the spatial and memory descriptions were evaluated by testing rats with damage to the hippocampal system in a series of experiments, independently manipulating the spatial and memory characteristics of a behavioral task. No dissociations were found when the spatial characteristics of the stimuli to be remembered were changed; lesions produced a similar deficit in both spatial and nonspatial test procedures, indicating that the hippocampus was similarly involved regardless of the spatial nature of the task. In contrast, a marked dissociation was found when the memory requirements were altered. Rats with lesions were able to perform accurately in tasks that could be solved exclusively on the basis of reference memory. They performed at chance levels and showed no signs of recovery even with extensive postoperative training in tasks that required working memory. In one experiment all the characteristics of the reference memory and working memory procedures were identical except the type of memory required. Consequently, the behavioral dissociation cannot be explained by differences in attention, motivation, response inhibition, or the type of stimuli to be remembered. As a result of these experiments we propose that the hippocampus is selectively involved in behaviors that require working memory, irrespective of the type of material (spatial or nonspatial) that is to be processed by that memory.

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