2000
DOI: 10.1016/s0165-0173(99)00089-2
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Epileptogenesis in immature rats following recurrent status epilepticus

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Cited by 53 publications
(59 citation statements)
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“…These changes could underlie the behavioral deficits and generalized epileptic discharges observed in adulthood (15,16). The most prominent changes observed were (a) altered intracortical microcircuitry development; (b) anticipated PV immunoreactivity in neocortical interneurons; (c) increased GAD-65 immunoreactivity; and (d) altered neocortical apoptotic process.…”
Section: Discussionmentioning
confidence: 99%
“…These changes could underlie the behavioral deficits and generalized epileptic discharges observed in adulthood (15,16). The most prominent changes observed were (a) altered intracortical microcircuitry development; (b) anticipated PV immunoreactivity in neocortical interneurons; (c) increased GAD-65 immunoreactivity; and (d) altered neocortical apoptotic process.…”
Section: Discussionmentioning
confidence: 99%
“…While the immature brain appears to be less vulnerable to the adverse effects of prolonged seizures than the mature brain 13 , seizures in the early life can be associated with later cognitive and behavioral disturbances, even in the absence of overt structural neuronal damage [14][15][16] . Previous study of our laboratory showed that 3 consecutive episodes of long-lasting pilocarpine-induced SE in developing rats (P7-9) is not able to promote neuronal loss but induces important electrographic and cognitive changes during adulthood 17 . Similarly, subtle impairments in intellectual performance have been reported in many individuals with a history of seizures in early life 18 .…”
mentioning
confidence: 85%
“…Furthermore, retrospective studies indicate that adults with mesial temporal lobe epilepsy report a high incidence of childhood status epilepticus 29 . Previously, our laboratory showed that although most of the animals submitted to SE (P7-9) did not develop spontaneous seizures in adulthood, they presented learning impairment and significant changes in cortical recordings, with episodes of complex spiking activity 17 . here we demonstrate increased temporal radial glia after injury induced by SE and delayed in radial glia disappearance.…”
Section: Fig 2 Details Of Cortical Radial Glia and Blood Vessels [Amentioning
confidence: 99%
“…21 Epileptogenesis refers to the events by which the normal brain becomes capable of producing epileptic seizures, i.e., the process by which neural circuits are converted from normal excitability to hyperexcitability. 56 As enumerated by White, 21 an appropriate animal model of epileptogenesis should share characteristics with human epilepsy, including similar pathology, a latent period following initial insult, chronic hyperexcitability and spontaneous seizures. Manipulations that produce prolonged seizures (Status Epilepticus -SE) in experimental animals have proven to satisfy all these criteria 57 .…”
Section: Experimental Epilepsymentioning
confidence: 99%