2024
DOI: 10.1101/2024.07.02.601732
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Epileptogenesis Inhibits the Circadian Clock and Reshapes the Diurnal Transcriptomic Rhythmicity in the Mouse Hippocampus

Radharani Benvenutti,
Danielle C. F. Bruno,
Matheus Gallas-Lopes
et al.

Abstract: Epileptogenesis is the process that leads the brain into epileptic activity. Clinical evidence shows that ∼90% of people with epilepsy present rhythmicity in the timing of their seizures presentation. However, whether the circadian clock is a key player during epileptogenesis remains unknown. Here, we triggered epileptogenesis in mice by the intra-amygdala injection of kainic acid and profiled by RNA sequencing their hippocampal diurnal mRNA rhythmicity. We show that epileptogenesis largely reshapes the hippoc… Show more

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