Epileptogenic Activity of Methicillin-Resistant Staphylococcus aureus (MRSA) Antibiotics in Rats

Rahman, Md. Ashequr; Ago, Jun; Matsumoto, Naotaka; Ishikawa, Takashi; Kamei, Chiaki

doi:10.1248/bpb.29.2035

Cited by 2 publications

(1 citation statement)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the other hand, Grondahl and Langmoen (5) reported that vancomycin caused no epileptogenic activity in rats. In addition, little work has been done to study the epileptogenic activity of teicoplanin, except our preliminary paper (6).…”

Section: Introductionmentioning

confidence: 99%

Epileptogenic Activity Induced by Teicoplanin and Effects of Some Antiepileptics in Mice

2008

Self Cite

View full text Add to dashboard Cite

Abstract. The present study was undertaken to clarify the epileptogenic activity induced by intracerebroventricular injection (i.c.v.) of methicillin-resistant Staphylococcus aureus (MRSA) antibiotics in mice. Teicoplanin (200 μg, i.c.v.) caused dose-related behavioral seizures such as head twitch and forelimb clonus. At the same time, the drug caused electroencephalographic (EEG) seizures characterized by spike-and-wave complex and a continuous spike with high amplitude. At a high dose (500 μg, i.c.v.), the drug caused a severe clonic convulsion followed by continuous spike and spike-and-wave complex on EEG. On the other hand, vancomycin caused no or almost no epileptogenic activity in both behavior and on EEG. Diazepam and sodium valproate dose-dependently antagonized epileptic seizures in behavior and on EEG induced by teicoplanin (500 μg, i.c.v.). In contrast, carbamazepine and ethosuximide caused no significant changes in both behavioral and EEG seizures induced by teicoplanin. From these findings, it can be concluded that teicoplanin may cause potent epileptogenic activity different from vancomycin when used clinically at extremely high doses. In addition, it may be that teicoplanin-induced seizure is closely related with the γ-amino butyric acid (GABA)-ergic mechanism.

show abstract

Section: Introductionmentioning

confidence: 99%

Epileptogenic Activity Induced by Teicoplanin and Effects of Some Antiepileptics in Mice

2008

Self Cite

View full text Add to dashboard Cite

show abstract

Teikoplaninin indüklediği nöbet

et al. 2017

View full text Add to dashboard Cite

Elli altı yaşında erkek hasta karaciğer nakli sonrası anastomoz darlığı ve kolanjit tanısı ile kliniğimize başvurdu. Hastaya perkütan transhepatik kolanjiografi (PTK) yapıldı. Kolanjit tanısı ile imipenem başlandı. Ancak ateş ve beyaz küre değerinde yükseklik olması üzerine imipenem tedavisinin 10. gününde teikoplanin eklendi. İlaç başlandıktan bir gün sonra tonik klonik epileptik nöbetleri oldu. Kranial bilgisayarlı tomografi (BT), elektroensefalografi (EEG) ve kranial magnetik rezonans görüntüleme (MRG) çekildi. Sadece MRG'de kronik iskemik değişiklikler saptandı. Laboratuvar analizinde kan sodyum 124 mEq/L saptanan hastaya replasman tedavisi yapıldı. Hastaya levetiracetam başlandı. Epileptik atakları tekrarlayan hastada metabolik asidoz gelişti ve entübe edildi. Teikoplanin verilmesinden hemen sonra başlaması ve diğer etiyolojik faktörlerin dışlanması nedeniyle nöbetlerin teikoplanine bağlı olabileceği düşünüldü ve hastanın ilacı kesildi. İlaç kesilmesi sonrası nöbetler kesildi. Ancak ventilatöre bağlı pnömoni gelişen hasta exitus oldu. Enfekte ve teikoplanin alan bir hastada nöbet varlığında ilaca bağlı nöbet akılda tutulmalıdır.

show abstract

Epileptogenic Activity of Methicillin-Resistant Staphylococcus aureus (MRSA) Antibiotics in Rats

Cited by 2 publications

References 17 publications

Epileptogenic Activity Induced by Teicoplanin and Effects of Some Antiepileptics in Mice

Epileptogenic Activity Induced by Teicoplanin and Effects of Some Antiepileptics in Mice

Teikoplaninin indüklediği nöbet

Contact Info

Product

Resources

About