2000
DOI: 10.1358/dot.2000.36.11.1136048
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Epinastine: An update of its pharmacology, metabolism, clinical efficacy and tolerability in the treatment of allergic diseases

Abstract: Epinastine is a potent antiallergic agent that has not only antihistaminic (H(1)) properties but also provides antileukotriene, anti-PAF and antibradykinin activities, which are associated with its antiallergic actions. Moreover, epinastine is very effective in inhibiting the release of chemical mediators from mast cells exposed to antigen. In addition, IL-8 release from eosinophils was inhibited by epinastine posttranscriptionally. Chemotatic movement of eosinophils was also blocked by epinastine. The increas… Show more

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Cited by 22 publications
(6 citation statements)
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“…최근 급속한 산업화로 인한 환경오염과 합성물질의 증가로 알레르기성 접촉성 피부염, 아토피 피부염 등 각종 피부 질환 이 증가하고 있다. 이러한 피부 질환 치료제로 항히스타민제, 면역억제제 및 부신피질 호르몬제 등이 이용되고 있으나 어지 럼증, 신독성, 골다공증, 표피위축, 고혈압 유발 등 많은 부 작용을 보이고 있으며 피부가 건강한 장벽의 기능을 회복하는 데 별다른 효과가 없는 것으로 알려져 있다 3,4,12) .…”
Section: 고 찰unclassified
“…최근 급속한 산업화로 인한 환경오염과 합성물질의 증가로 알레르기성 접촉성 피부염, 아토피 피부염 등 각종 피부 질환 이 증가하고 있다. 이러한 피부 질환 치료제로 항히스타민제, 면역억제제 및 부신피질 호르몬제 등이 이용되고 있으나 어지 럼증, 신독성, 골다공증, 표피위축, 고혈압 유발 등 많은 부 작용을 보이고 있으며 피부가 건강한 장벽의 기능을 회복하는 데 별다른 효과가 없는 것으로 알려져 있다 3,4,12) .…”
Section: 고 찰unclassified
“…In addition, the suppression of CD54 expression on keratinocytes may inhibit T‐cell adherence to the epidermis during the development of CHS. Epinastine has a potential to exert a therapeutic effect on Th1‐mediated skin disorders, as it depresses pruritus in patients with not only AD (58) but also Th1‐mediated psoriasis (59). Accordingly, it was approved by the ministry in Japan as a drug for psoriasis as well as eczematous diseases.…”
Section: Antihistamine Drugs As a Modulator Of Keratinocyte Chemokinementioning
confidence: 99%
“…Epinastine is a histamine H 1 receptor antagonist and a nonsedative antiallergic drug [1, 2]. Based on its physicochemical properties, such as hydrophilicity and cationic charge in the physiological pH range, it was assumed that epinastine does not readily enter the central nervous system, and indeed epinastine penetrates very poorly into the human brain as shown by positron emission tomography (PET) [3–5]. The absolute bioavailability of epinastine is about 40% and a linear relationship was demonstrated between epinastine dose and both C max and AUC after administration of epinastine in the dose range of 10–40 mg [6].…”
Section: Introductionmentioning
confidence: 99%