Epinephrine

Ventricular Tachycardia Associated with Thyrotoxicosis

“…McIntyre (1931) produced tachycardia in denervated dogs' hearts by thyroxine, and experimental evidence suggests that it increases the sensitivity of cardiac muscle to adrenaline. Rosenblum, Hahn, and Levine (1933) produced thyrotoxicosis in animals by thyroid feeding and then studied the effects of adrenaline infusions on their cardiac rhythm by electrocardiogram. Paroxysmal ventricular tachycardia was produced in all animals with doses of adrenaline too small to alter the cardiac rhythm of normal controls.…”

Adrenaline in Hyperthyroidism and Insulin Hypoglycaemia

“…Hyperthyroid subjects have a striking increase in sensitivity to adrenaline and noradrenaline (Rosenblum et al, 1933;Peltola, 1951 ;Schneckloth et al, 1953;Brewster et al, 1956). Many observers have noted changes in adrenaline content of adrenal glands in animals in which hyperthyroidism was produced by giving thyroxine (Goodall, 1951;Hokfelt, 1951;Pekkarinen et al, 1951 ;Durlach et al, 1955).…”