1980
DOI: 10.1172/jci109840
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Epinephrine plasma metabolic clearance rates and physiologic thresholds for metabolic and hemodynamic actions in man.

Abstract: A B S T R A C T To determine the plasma epinephrine thresholds for its metabolic and hemodynamic actions and plasma epinephrine metabolic clearance rates, 60-min intravenous epinephrine infusions at nominal rates of0.1, 0.5, 1.0, 2.5, and 5.0,ug/min were performed in each of six normal human subjects. These 30 infusions resulted in steady-state plasma epinephrine concentrations ranging from 24 to 1,020 pg/ml. Plasma epinephrine thresholds were 50-100 pg/ml for increments in heart rate, 75-125 pg/ml for increme… Show more

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Cited by 563 publications
(236 citation statements)
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“…The thresholds for the other effects of epinephrine (such as changes in heart rate, glucose, alanine, or growth hormone) are variable, ranging from twice to ten times the basal levels. 23 Our observations suggest that further controlled studies are warranted to examine the predictive value and dose-related threshold for T-wave changes.…”
Section: Discussionmentioning
confidence: 80%
“…The thresholds for the other effects of epinephrine (such as changes in heart rate, glucose, alanine, or growth hormone) are variable, ranging from twice to ten times the basal levels. 23 Our observations suggest that further controlled studies are warranted to examine the predictive value and dose-related threshold for T-wave changes.…”
Section: Discussionmentioning
confidence: 80%
“…Similarly the increase in both growth hormone and cortisol may have r-adrenoceptor blockade and hypoglycaemia been due to the effect of increased levels of circulating catecholamines on secretion of these hormones (Blackard & Hubbel, 1970;Taylor & Fishman, 1988). Direct adrenergic stimulation of glucagon secretion has been reported by some (Gerich et al, 1976), but not all groups (Clutter et al, 1980), and one might have expected ,-adrenoceptor blockers to reduce glucagon release although this would be offset to some extent by the greater plasma adrenaline concentration.…”
Section: Resultsmentioning
confidence: 95%
“…22,23 During hormone infusions, the plasma threshold concentration for cardiovascular and metabolic changes is about 10 times lower for adrenaline than for noradrenaline. 10,22 Thus, it is impossible to mimic physiological events completely by noradrenaline infusions, and for these reasons adrenaline was chosen for the present study. The threshold for metabolic effects observed during adrenaline infusion in this experiment was well below the concentrations observed during ordinary activities like standing or mild exercise.…”
Section: Discussionmentioning
confidence: 99%