Epiphytic Acampe ochracea orchid relieves paracetamol-induced hepatotoxicity by inhibiting oxidative stress and upregulating antioxidant genes in in vivo and virtual screening

Ahmed, Ayaz; Ma, Rahman; Hossen, Md. Amjad; Reza, A. S. M. Ali; Islam, Md. Shahidul; Rashid, Md. Mamunur; Rafi, Md. Khalid Juhani; Siddiqui, Md. Tanvir Ahmed; Al-Noman, Abdullah; Uddin, Nazim

doi:10.1016/j.biopha.2021.112215

Cited by 18 publications

(11 citation statements)

References 66 publications

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“…Methanol extract of S. aqueum leaves contained a number of 87 different compounds rich in flavonoids, for example, myricetin rhamnoside, myrigalone‐G pentoside, quercetin galloyl‐pentoside, cryptostrobin, in which myrigalone‐B and myrigalone‐G were the major flavonoid compounds (A. A. Ahmed et al., 2021 ; Sobeh, Mahmoud, et al., 2018 , 2018 ). Six flavonoids (e.g., 4‐hydroxybenzaldehyde, myricetin‐3‐O‐rhamnoside, europetin‐3‐O‐rhamnoside, phloretin, myrigalone‐G, and myrigalone‐B) were isolated from the ethanol leaf extracts of S .…”

Section: Phytochemical Constituentsmentioning

confidence: 99%

Traditional uses, pharmacological activities, and phytochemical constituents of the genus Syzygium: A review

Uddin

Hossain

Reza

et al. 2022

Food Science & Nutrition

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This comprises medicinal plants not only important for the treatment of diseases but also as potential material for maintaining good health and conditions. Better cultural acceptability, better compatibility and adaptability with the human body, and lesser side effects of plants made many countries in the world to depend on herbal medicine for their primary health care (Bari et al., 2021;CHOWDHURY et al., 2021;Hoque et al., 2021). For centuries, plants are being widely used for their natural resources isolated from various parts of a plant and have been used in the treatment of human diseases. Moreover, some of these plants produce edible fruits, while others simply produce dazzling flowers, which are so attractive and important economically as well.The knowledge of traditional medicine supports all other systems of medicine such as Ayurveda, Siddha, Unani, and even modern

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Section: Phytochemical Constituentsmentioning

confidence: 99%

Traditional uses, pharmacological activities, and phytochemical constituents of the genus Syzygium: A review

Uddin

Hossain

Reza

et al. 2022

Food Science & Nutrition

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“…Many disorders such as inflammation, pain and neurodegenerative diseases are related to free radical activity. 27 Antioxidants have the ability to scavenge these free radicals and are therefore useful for management of these disorders. 28 The DPPH scavenging free radical assay is useful to determine the antioxidant effect of plant extracts.…”

Section: Discussionmentioning

confidence: 99%

Pharmacological insights into Chukrasia velutina bark: Experimental and computer‐aided approaches

Jahan

Sakib

Alam

et al. 2022

Anim Models and Exp Med

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Background: Chukrasia velutina is an enthnomedicinally used plant reported to have significant medicinal values. The present study aimed to explore the pharmacological activities of bark methanol extract using in vitro, in vivo and in silico models. Methods:The study was designed to investigate the pharmacological effects of methanol extract of Chukrasia velutina bark (MECVB) through in vitro, in vivo and in silico assays. Analgesic activity was tested using formalin-induced nociception and acetic acid-induced writhing assays while the antipyretic effect was tested using yeast-induced hyperthermia in mice model. The antioxidant effect was tested using the DPPH and reducing power assay and the cytotoxic screening was tested using the brine shrimp lethality bioassay. In addition, in silico studies were conducted using computer aided methods. Results:In the acetic acid-induced writhing assay, the extract showed 28.36% and 56.16% inhibition of writhing for doses of 200 and 400 mg/kg, respectively. Moreover, a dose-dependent formalin-induced licking response was observed in both early and late phase. In yeast-induced pyrexia, the MECVB exhibited (p < 0.05) antipyretic effect. The extract demonstrated an IC 50 value of 78.86 μg/ml compared with ascorbic acid (IC 50 23.53 μg/ml) in the DPPH scavenging assay. The compounds sitosterol, 5,7-dimethoxycoumarin and scopoletin were seen be effective in molecular docking scores against COX-I (2OYE), COX-II (6COX) and human peroxiredoxin 5 (1HD2). In ADME/T analysis, 5,7-dimethoxycoumarin and scopoletin satisfied Lipinski's rule of five and thus are potential drug candidates. Conclusion:The bark of Chukrasia velutina showed significant analgesic and antipyretic properties and is a potential source of natural anti-oxidative agents.

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“…Natural medicines based on plant/herbs have been widely used owing to their therapeutic efficacy since primitive ages. Natural substances are extensively used in the pharmaceutical, biopharmaceutical, and food supplement and dietary nutritional industries to prepare various natural remedies, minerals, nutritional supplements, and medicine for numerous diseases ( Ahmed et al., 2021 ; Babar et al., 2019 , 2020 ; Haque et al., 2017 ; Hossain et al., 2020 ). Owing to their abundant source of biologically active secondary metabolites, the significance of traditional medicines in managing a broad variety of diseases is continually increasing ( Akter et al., 2020b ; Haque et al., 2020 ; Islam et al., 2020 ; Rahman et al., 2021a ).…”

Section: Discussionmentioning

confidence: 99%

Antioxidative role of palm grass rhizome ameliorates anxiety and depression in experimental rodents and computer-aided model

Hoque

Ahmad

Chakrabarty

et al. 2021

Heliyon

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Palm grass (Curculigo recurvata) is an ethnomedicinally important herb reported to have significant medicinal values. The present study aimed to evaluate the antidepressant and anxiolytic activities of a methanol extract of C. recurvata rhizome (Me-RCR) through different approaches. The antidepressant and anxiolytic properties of Me-RCR were assessed by using elevated plus maze (EPM), hole-board (HBT), tail suspension (TST), and forced swimming (FST) tests in Swiss Albino mice. The in-depth antioxidative potential of Me-RCR was also evaluated through DPPH radical scavenging activity, ferric-reducing power capacity, total phenolic, flavonoid, flavonol, and antioxidant content analysis. Computational investigations were performed using computer-aided methods for screening the anxiolytic, antidepressant, and antioxidative activities of the selected lead molecules. Treatment with Me-RCR (200 and 400 mg/kg, b.w.) notably increased the number of open arm entries and the time spent in the EPM test. In the HBT, Me-RCR exhibited significant anxiolytic activity at a dose of 200 mg/kg, whereas similar activity was observed at 400 mg/kg in the EPM test. Me-RCR significantly decreased the immobility time in a dose-dependent manner in both TST and FST. The IC 50 for DPPH and reducing power capacity assay were found

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Epiphytic Acampe ochracea orchid relieves paracetamol-induced hepatotoxicity by inhibiting oxidative stress and upregulating antioxidant genes in in vivo and virtual screening

Cited by 18 publications

References 66 publications

Traditional uses, pharmacological activities, and phytochemical constituents of the genus Syzygium: A review

Traditional uses, pharmacological activities, and phytochemical constituents of the genus Syzygium: A review

Pharmacological insights into Chukrasia velutina bark: Experimental and computer‐aided approaches

Antioxidative role of palm grass rhizome ameliorates anxiety and depression in experimental rodents and computer-aided model

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