Epiretinal membrane-induced intraretinal neovascularization

Giachos, Ioannis; Chalkiadaki, Evangelia; Andreanos, Konstantinos; Symeonidis, Chrysanthos; Charonis, Alexandros; Georgalas, Ilias; Rotsos, Tryfon

doi:10.1016/j.ajoc.2021.101180

Cited by 4 publications

(5 citation statements)

References 9 publications

(8 reference statements)

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Section: Discussionmentioning

confidence: 96%

“…8 Giachos et al reported a case of a 71-year-old male who presented with an ERM, a subhylaoid and intraretinal hemorrhage which was confirmed using multimodal imaging and described its treatment response with intravitreal Ranibizumab. 9 Lee et al in their report have described an ERN in a patient with RP and have shown reduction in vascularity post treatment with intravitreal bevazizumab. 10 Ayachit et al described ERN in seven eyes of four patients with Mac Tel 2 and with six of the seven eyes showing a communication with the intraretinal vascular network and with none of the eyes showing MNV.…”

Section: Np56mentioning

confidence: 96%

See 1 more Smart Citation

Multimodal imaging of epiretinal neovascularization associated with type 3 macular neovascularization

Manayath

Ninan

Verghese

et al. 2023

European Journal of Ophthalmology

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Purpose To report a case of type 3 macular neovascularization presenting with an epiretinal neovascularization. Methods Case report. Results A 65-year-old gentleman presented with complaints of reduced vision in the left eye (LE) having a best corrected visual acuity (BCVA) of 20/200. Based on fundus examination and multimodal imaging findings he was diagnosed with type 3 macular neovascularization (MNV). An additional unusual finding was the presence of an epiretinal membrane (ERM) and epiretinal neovascularization (ERN), with the latter finding being confirmed on optical coherence tomography angiography (OCTA). He underwent three doses of intravitreal ranibizumab injection following which there was reduction in the epiretinal vascularity. Conclusions Multimodal imaging of this case highlights the presence of epiretinal neovascularization associated with type 3 MNV, which has not been reported previously.

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Section: Discussionmentioning

confidence: 96%

Section: Np56mentioning

confidence: 96%

Multimodal imaging of epiretinal neovascularization associated with type 3 macular neovascularization

Manayath

Ninan

Verghese

et al. 2023

European Journal of Ophthalmology

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“…Giachos et al declared that it is feasible that intraretinal neovascularization in an idiopathic ERM occurred because of, or near, preexisting ERMs. Initially, they considered a perimacular branch retinal vein occlusion, a congenital retinal anomaly, an age-related macular degeneration (AMD) lesion, and macular telangiectasia as differential diagnoses [ 7 ]. However, they were ultimately ruled out until IVEM was the final diagnosis.…”

Section: Discussionmentioning

confidence: 99%

“…Managing IVEM can be challenging. Since it a rare, the only published case reports had different follow-up periods and treatment approaches that incorporated observation, anti-VEGF therapy, vitrectomy, and combined treatment [ 2 , 3 , 5 – 7 ]. Therefore, treatment outcomes may vary.…”

Section: Discussionmentioning

confidence: 99%

Multimodal Imaging of an Idiopathic Vascularized Epiretinal Membrane: A Case Report

Osorio-Landa,

Oliver-Aguirre,

Henaine-Berra

et al. 2024

Am J Case Rep

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Patient: Male, 70-year-old Final Diagnosis: Vascularized epiretinal membrane Symptoms: Asymptomatic Clinical Procedure: — Specialty: Ophthalmology Objective: Rare disease Background: Idiopathic epiretinal membranes (ERMs) are commonly associated with fibrovascular tissue, primarily observed in ischemic retinopathies. However, idiopathic vascularized ERMs (IVEM) are exceedingly rare, and their pathogenesis and clinical course remain poorly understood. This report aims to contribute to the limited literature on IVEM, shedding light on its characteristics and potential implications for patient management. Case Report: We present the case of a 70-year-old man diagnosed with idiopathic ERM in the left eye, revealing a neovascular complex within the membrane. Despite the absence of ocular symptoms and medical history, multimodal imaging using the Nidek Mirante, including spectral domain optical coherence tomography (SD-OCT) and optical coherence tomography angiography (OCT-A), revealed a thick pre-retinal hyper-reflective line with a partial posterior vitreous detachment and an abnormal vascular complex resembling a pruned-vascular-tree pattern. Notably, fluorescein angiography confirmed hyperfluorescence and leakage corresponding to the observed vessels. Despite the rarity of IVEM, the patient remained asymptomatic, and observation was deemed appropriate. Conclusions: IVEM poses a rare challenge in clinical practice, necessitating a comprehensive understanding of its features and potential complications. While the etiopathogenesis remains unclear, hypertension has been proposed as a contributing factor. This case adds valuable insights to the growing literature on IVEM, emphasizing the importance of multimodal imaging in diagnosis and decision-making. Given the limited reports and varied treatment outcomes, managing IVEM requires careful consideration of observation and various therapeutic approaches, highlighting the need for further research to optimize patient care.

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“…One of the phenomena observed in the course of PDR is capillary oclusion in the retina, which, by causing hypoxia, increases the expression of VEGF by the cells that build the retina (32). Pathological retinal angiogenesis promotes the formation of subretinal hemorrhages, which in turn promotes the development of ERM (33).…”

Section: Cytokine or Molecule Descriptionmentioning

confidence: 99%

Pathophysiology and clinical aspects of epiretinal membrane – review

Ożóg,

Nowak-Wąs,

Rokicki

2023

Front. Med.

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The epiretinal membrane (ERM) is a pathological tissue formed at the vitreoretinal interface. The formation of this tissue is associated with numerous symptoms related to disturbances of vision. These types of lesions may arise idiopathically or be secondary to eye diseases, injuries and retinal surgeries. ERM tissue contains numerous cell types and numerous cytokines, which participate in its formation. The aim of this paper is to summarize information about the etiology, epidemiology, pathophysiology and treatment of ERM, with a brief description of the main cells that build the ERM – as well as the cytokines and molecules related to ERM pathogenesis – being provided in addition.

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Epiretinal membrane-induced intraretinal neovascularization

Cited by 4 publications

References 9 publications

Multimodal imaging of epiretinal neovascularization associated with type 3 macular neovascularization

Multimodal imaging of epiretinal neovascularization associated with type 3 macular neovascularization

Multimodal Imaging of an Idiopathic Vascularized Epiretinal Membrane: A Case Report

Pathophysiology and clinical aspects of epiretinal membrane – review

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