Accumulation of anoxic sediments in the North Atlantic from Barremian through Turanian time (Early to middle Cretaceous) was apparently controlled mainly by local conditions, although global climatic and oceanographic factors may have played a supporting role. Evidence does not support the popular hypothesis developed over the past few years of global or ocean-wide anoxia. The data contradicting this hypothesis are based on a reevaluation of criteria for identifying sediments that accumulated in anoxic water, a critical reappraisal of reported world-wide occurrences of anoxic sediments of these ages, and an examination of the spatial and temporal distribution of anoxic sediments in the North Atlantic and elsewhere. A model is proposed in which the earliest anoxic sediments of Cretaceous age in the North Atlantic were deposited in deep restricted basins. By middle Cenomanian time (about 97 m.y. ago), however, sluggish circulation had led to a gradual expansion of the oxygen-minimum layer, permitting deposition of anoxic sediments in nonbasinal settings. The expansion of the oxygen-minimum layer caused the calcite compensation depth to rise, promoting oxidation of organic carbon and causing contraction of the oxygen-minimum layer. The development of anoxia was thus self-damping. Anoxia effectively disappeared by early Senonian time (88 m.y. ago) when improved circulation created oceans more like those of the present. Some evidence indicates that enhanced productivity and upwelling may have played a local role in fostering anoxia, but most data suggest that worldwide marine productivity was generally not high during Early and middle Cretaceous time.