The establishment, development and abandonment and/or destruction of ancient civilizations were catalytically controlled by geomorphic features such as lakes and rivers and the climate. This paper examined the possible influence of tectonism and climate on six habitations of the ancient Vaigai River Basin civilization in South India, using multiple proxies such as grain size, geochronology and geochemistry of the sedimentary archives. The tectonic setting of the basin changed between the active margin and passive margin; the discriminant diagrams suggested varying provenance and changing climatic conditions over the mid‐ and‐late Holocene. Tectonic activism and quiescence, base‐level change in the channel morphology led to the burial/marooning of the first habitation surface. Overall, arid conditions were punctuated with catastrophic flooding and peak discharge (flood) destroyed the second, third and fourth habitation sites. These flooding events were characterized by moderate weathering (CIA) and high values of Al, Fe and Rb/Sr and low Ca/Mg in the sediment records. The abandonment/destruction of the fifth habitation also occurred during an arid interval (droughts), possibly caused by weak monsoon. Along with the interactions between tectono‐climatic and fluvial geomorphic factors, the new results provided avenues to (a) check and recognize the archives for 8.2 and 4.2 ka‐like events in this part of the world, and (b) the utility of integrated analyses to constrain on the civilizational histories of the mankind.