Cosmogenic nuclides produced in quartz may either decay or accumulate while sediment is moved through a river basin. A change in nuclide concentration resulting from storage in a floodplain is potentially important in large drainage basins in which sediment is prone to repeated burial and remobilization as a river migrates through its floodplain. We have modeled depth-and time-dependent cosmogenic nuclide concentration changes for 10 Be, The cosmogenic nuclide composition of old deposits in currently inactive floodplains that have been isolated for periods of millions of years from the river that once deposited them are predicted to either increase or decrease in C, nuclide concentrations modeled for the in situ-produced variety of this nuclide are, however, sensitive to floodplain storage on residence times of < 20 ky. 10 Be and 26 Al concentration, depending on the depositional depth. These conditions can be evaluated using the 26 Al/ 10 We illustrate these models with examples from the Amazon basin. As predicted, modern bedload collected from an Amazon tributary, the Bolivian Beni River, shows no systematic change in nuclide concentration as sediment is moved through 500 km of floodplain by river meandering. In contrast, in the central Amazon floodplain currently untouched by the modern river system, low Be ratio that readily discloses the depth and duration of storage.26 Al/ 10 The important result of this analysis is that in all likely cases of active floodplains, cosmogenic Be ratios account for minimum burial depths of 5 to 10 m for a duration of > 5 My. 10 Be and 26 Al concentrations remain virtually unchanged over the interval sediment usually spends in the basin. Thus, spatially-averaged denudation rates of the sediment-producing area can be inferred throughout the entire basin, provided that nuclide production rates are scaled for the altitudes of the sediment-producing area only, because floodplain storage does not modify nuclide concentrations introduced from the sediment source area.