Epithelial Abnormalities: Glandular

Covell, Jamie L.; Wilbur, David C.; Guidos, Barbara J.; Lee, Kenneth R.; Chhieng, David C.; Mody, Dina R.

doi:10.1007/978-1-4612-2042-8_6

Cited by 16 publications

(37 citation statements)

References 14 publications

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“…1 d-i) The presence of neutrophilic bags adjacent to the atypical cell clusters is highly suggestive of endometrial origin, which was evident in a few of our cases ( Fig. 3 g, h) [2] . AIS was first described by Friedell and Mackay in 1953.…”

Section: Discussionmentioning

confidence: 93%

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The Significance of Glandular Cells on Conventional Cervicovaginal Smears: Experience from a Tertiary Care Hospital in Coastal India

Suresh

Kini

Minal³

et al. 2017

Acta Cytologica

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Introduction: Glandular lesions of the female genital tract (FGT) are quite uncommon compared to squamous lesions. Their cytological diagnosis is difficult because of their architectural and cytological complexity, as well as the lack of experience of many cytopathologists in this field. The aim of this study was to determine the significance of Papanicolaou (Pap) smears in the diagnosis of glandular FGT lesions. Methodology: All Pap smears reported during the period of January 2012 to December 2013 were retrieved. Cytohistopathological correlation was done. Results: Among 7,609 Pap smears, squamous epithelial abnormalities were seen in 110 cases (1.5%) and glandular cell abnormalities in 32 cases (0.42%). Among the glandular abnormalities, we encountered 18 cases of atypical glandular cells (AGC) not otherwise specified, 4 cases of endocervical-type AGC and 4 cases favoring neoplastic-type AGC, 2 cases of adenocarcinoma of the endocervical type, 3 cases of adenocarcinoma of the endometrial type, and 1 case of extrauterine adenocarcinoma. Histopathological correlation was available in 12 cases (37.5%). Eighty-three percent showed premalignant or malignant lesions on histopathology. Conclusion: As glandular epithelial lesions are associated with premalignant and malignant FGT lesions, in patients with cytological diagnosis of glandular epithelial abnormalities, it is mandatory to undergo colposcopic examination with endocervical and endometrial curettage.

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Section: Discussionmentioning

confidence: 93%

“…Accordingly, presence of glandular cells of endocervical or endometrial origin should be studied whenever possible. Furthermore, adenocarcinoma in situ (AIS) has been segregated into another distinct category [1][2][3] .…”

Section: Introductionmentioning

confidence: 99%

The Significance of Glandular Cells on Conventional Cervicovaginal Smears: Experience from a Tertiary Care Hospital in Coastal India

Suresh

Kini

Minal³

et al. 2017

Acta Cytologica

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“…The diagnostic category and the terminology of atypical glandular cell (AGC), has been widely used since it was first established at the 2001 Bethesda convention (Covell et al, 2003). Before 2001, AGC within The Bethesda System (TBS) were mentioned as atypical glandular cells of undetermined significance (AGUS).…”

Section: Cervical Cytologymentioning

confidence: 99%

“…(Covell et al, 2003). However, subclassification of AGC has yet to be proved clinically effective, and although The Bethesda Committee and many others have studied cytologic criteria important in subclassification, these criteria have not been tested vigorously.…”

Section: Definition Of Architectural Features -Glandular Crowdingmentioning

confidence: 99%

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Cervical Glandular Intraepithelial Neoplasia (CGIN)

Izadi-Mood¹,

Sarmadi²,

Sotoudeh³

2012

Intraepithelial Neoplasia

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Minimal deviation endometrioid adenocarcinoma of the cervix: Report of three cases with exfoliative cytology

Odashiro¹,

Odashiro²,

Nguyen

2006

Diagnostic Cytopathology

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Three histologically confirmed minimal deviation endometrioid adenocarcinomas (MDEA) of the uterine cervix with cytologic evaluation by cervical scraping were reviewed. The smears were cellular and showed tall columnar tumor cells arranged in monolayered sheets with nuclei in palisade at free borders, rosettes, and irregular clusters. Cellular strips with palisading nuclei was noted in one case. The individual tumor cells showed monomorphic, round or oval, hyperchromatic nuclei with chromatin clumping, small nucleoli, and granular, nonvacuolated cytoplasm with cytoplasmic extensions or tails. The smear background showed a variable amount of necrotic debris admixed with polymorphonuclear leukocytes in two cases. The cytologic manifestations of those three cervical MDEAs overlapped, to some extents, with those of a cervical adenocarcinoma in situ and with those of a well-differentiated endometrial adenocarcinoma invading the cervix.

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Epithelial Abnormalities: Glandular

Cited by 16 publications

References 14 publications

The Significance of Glandular Cells on Conventional Cervicovaginal Smears: Experience from a Tertiary Care Hospital in Coastal India

The Significance of Glandular Cells on Conventional Cervicovaginal Smears: Experience from a Tertiary Care Hospital in Coastal India

Cervical Glandular Intraepithelial Neoplasia (CGIN)

Minimal deviation endometrioid adenocarcinoma of the cervix: Report of three cases with exfoliative cytology

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