Epithelial Dysplasia in Cancerous and Noncancerous Esophagi

Satô, Eiichi; Tokunaga, Masayoshi; Sakae, Kiyohiro; Mukada, Takeo; Sasano, Nobuaki

doi:10.1620/tjem.124.117

Cited by 19 publications

(3 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In humans, Ushigome et al (1967) examined a total resected esophagus with subserial sections and speculated that epithelial dysplasia was the forerunner of carcinoma in situ. This report was supported by others (Sato et al, 1978;Takubo et al, 1981) and the concept appears to be generally accepted now. Napalkov and Pozhariski (1969) demonstrated that papillomas can progress to carcinoma.…”

Section: Referencessupporting

confidence: 86%

The role of alkaline reflux in esophageal carcinogenesis induced by N‐amyl‐N‐methylnitrosamine in rats

Seto

Kobori

Shimizu

et al. 1991

Intl Journal of Cancer

View full text Add to dashboard Cite

It is now accepted that the incidence of esophageal carcinoma is highest in the middle thoracic region. Esophageal carcinoma after gastrectomy, however, has a tendency to develop in the lower thoracic region. These studies suggest a possible correlation between the development of esophageal carcinoma and gastrectomy, i.e., alkaline reflux into the esophagus. To elucidate this correlation, the role of alkaline reflux of duodenal contents in the development of esophageal squamous-cell carcinoma induced by N-amyl-N-methylnitrosamine (AMN) was investigated in Wistar rats. The animals were divided into 3 groups; gastrectomized rats with or without regurgitation of duodenal contents into the esophagus, and control rats without gastrectomy. All received low doses of AMN for 8 weeks and were subsequently killed for pathological examination. Esophageal squamous-cell carcinomas were found only in gastrectomized rats with regurgitation. The carcinomas were found exclusively in areas of reflux esophagitis and were accompanied by severe dysplasia. Our results indicate that alkaline reflux of duodenal contents strongly contributes to the development of esophageal squamous-cell carcinoma.

show abstract

Section: Referencessupporting

confidence: 86%

The role of alkaline reflux in esophageal carcinogenesis induced by N‐amyl‐N‐methylnitrosamine in rats

Seto

Kobori

Shimizu

et al. 1991

Intl Journal of Cancer

View full text Add to dashboard Cite

show abstract

“…T h e concept of field change in epithelial tissues undergoing malignant transformation has previously been accepted for the urinary tract (Koss et al, 1974;Paulson et al, 1982), the colon (Filipe, 1974;Traynor et al, 1981;Habib et al, 1984), the breast (Gallagher and Martin, 1969;Wellings et al, 1975), the pancreas (Col1ins etal., 1966), and the lung (Fontana et al, 1975) and has been suggested for the esophagus in certain geographical regions (Sato et al, 1978). In at least some of these organs, the existence of field change has been causally related to recurrence of tumor after primary excision.…”

Section: Discussionmentioning

confidence: 98%

“…Another possibility, however, is that the esophageal mucosa of patients with esophageal cancer is inherently unstable (i.e., that a "field change" has occurred) and that this unstable mucosa subsequently progresses to frank malignancy. A number of previous studies support the concept that multifocal or extensive dysplastic changes are present in many patients with squamous cell carcinoma of the esophagus (Sato et al, 1978;Ushigome et al, 1967; T h e Coordinating Groups for the Research of Esophageal Carcinoma, Honan Province and Chinese Academy of Medical Sciences, 1975;Goran et al, 1984). With conventional light microscopy, however, the majority of patients with resection margins clear of tumor have no such dysplastic changes present at the resection margins.…”

Section: Introductionmentioning

confidence: 89%

Unsuspected field changes in the esophageal mucosa of patients with esophageal cancer

et al. 1990

View full text Add to dashboard Cite

The diagnosis of esophageal carcinoma carries an extremely poor prognosis. Even after apparently curative resection, with histologically normal resection margins, there is a high incidence of locally recurrent disease. This study was performed to determine if cell surface morphological abnormalities, indicative of a "field change," are present in the esophageal mucosa of patients with squamous carcinoma of the esophagus. Seven patients with squamous cell carcinoma of the esophagus and seven patients with a normal esophagus were studied. Biopsies were examined using both light and scanning electron microscopy; they were taken from the midesophagus in the normal group and from the tumor, the normal mucosa adjacent to the tumor, and the proximal surgical resection margin in the tumor group. There was a characteristic pattern of abnormalities present in both the mucosa adjacent to tumor and the resection margin, indicative of a field change. The microplicae on the cell surfaces were reduced in number and were unfolded, and defects were found in the extracellular matrix giving rise to intercellular fissures. These changes reflect increased cell turnover and increased cell exfoliation. We conclude that scanning electron microscopy can detect widespread changes in the esophageal mucosa of patients with esophageal cancer that are not detectable by light microscopy. The fact that such field changes exist as far as the proximal surgical resection margin may help explain locally recurrent disease after apparently curative surgery.

show abstract

Small cell carcinoma (non-oat cell type) of the esophagus concomitant with invasive squamous cell carcinoma and carcinoma in situ. A case report

Sato¹,

Mukai²,

Ando³

et al. 1986

Cancer

View full text Add to dashboard Cite

A case of double primary invasive carcinoma of the esophagus, consisting of well-differentiated squamous cell carcinoma and non-oat cell small cell carcinoma without squamous differentiation, is presented. This is the first reported case of a double or multiple primary invasive carcinoma of the esophagus in which one component is small cell carcinoma (oat cell or non-oat cell). Furthermore, the mucosal epithelium around the non-oat cell small cell carcinoma revealed multiple dysplasia and carcinoma in situ. These lesions were definitely separated from the invasive carcinoma and from each other. The results suggest that pure non-oat cell small cell carcinoma of the esophagus without squamous differentiation is derived from the esophageal squamous epithelium, and is a variant of squamous cell carcinoma.

show abstract

Epithelial Dysplasia in Cancerous and Noncancerous Esophagi

Cited by 19 publications

References 7 publications

The role of alkaline reflux in esophageal carcinogenesis induced by N‐amyl‐N‐methylnitrosamine in rats

The role of alkaline reflux in esophageal carcinogenesis induced by N‐amyl‐N‐methylnitrosamine in rats

Unsuspected field changes in the esophageal mucosa of patients with esophageal cancer

Small cell carcinoma (non-oat cell type) of the esophagus concomitant with invasive squamous cell carcinoma and carcinoma in situ. A case report

Contact Info

Product

Resources

About